integrin

noun in·te·grin \ ˈin-tə-grən \
Updated on: 16 Nov 2017

Definition of integrin

: any of various glycoproteins found on cell surfaces that are involved in the adhesion of cells (such as T cells) to other cells (such as endothelial cells) or to extracellular material (such as fibronectin or laminin) and mediate various biological processes (such as phagocytosis, wound healing, and embryogenesis)

Recent Examples of integrin from the Web

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'integrin.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

Origin and Etymology of integrin

integr- (from integral membrane protein complex) + 1-in


Medical Dictionary

integrin

noun in·te·grin \ ˈin(t)-ə-grən \

medical Definition of integrin

: any of various glycoproteins found on cell surfaces that are involved in the adhesion of cells (such as T cells) to other cells (such as endothelial cells) or to extracellular material (such as fibronectin or laminin) and mediate various biological processes (such as phagocytosis, wound healing, and embryogenesis)
Note: Integrins are composed of two dissimilar polypeptide chains (called α and β respectively) that extend through the cell membrane and vary in composition, which can influence their biological activity (such as the specificity of the ligand that they will bind).
  • Through these 20 or more integrins, the [extracellular] matrix sends cells various signals that regulate what genes are active, ultimately influencing whether cells proliferate, specialize, migrate, or even kill themselves.
  • —Richard MonasterskyScience News30 Aug. 1997
  • Early on we understood that integrins consist of two protein chains, or subunits. The subunit designated “alpha” is today known to have about 15 variants, and the “beta” subunit has about eight variants.
  • —Alan F. HorwitzScientific AmericanMay 1997

Seen and Heard

What made you want to look up integrin? Please tell us where you read or heard it (including the quote, if possible).

Love words? Need even more definitions?

Subscribe to America's largest dictionary and get thousands more definitions and advanced search—ad free!

WORD OF THE DAY

sticky or viscid

Get Word of the Day daily email!

Test Your Vocabulary

Find the Cousins

  • a-large-tree-with-many-branches
  • Which pair shares a common word ancestor?
Name That Thing

Test your visual vocabulary with our 10-question challenge!

TAKE THE QUIZ
SCRABBLE® Sprint

Test Your Knowledge - and learn some interesting things along the way.

TAKE THE QUIZ

Love words? Need even more definitions?

Subscribe to America's largest dictionary and get thousands more definitions and advanced search—ad free!