insoluble

adjective

in·​sol·​u·​ble (ˌ)in-ˈsäl-yə-bəl 

: not soluble: such as

a

: incapable of being dissolved in a liquid and especially water

also : soluble only with difficulty or to a slight degree

b

: having or admitting of no solution or explanation

an insoluble problem

c

archaic : indissoluble

insolubility

(ˌ)in-ˌsäl-yə-ˈbi-lə-tē 

noun

insoluble noun

insolubleness

(ˌ)in-ˈsäl-yə-bəl-nəs 

noun

insolubly

(ˌ)in-ˈsäl-yə-blē 

adverb

Synonyms of insoluble

• impossible
• hopeless

Examples of insoluble in a Sentence

a substance insoluble in water

the seemingly insoluble mystery concerning the identity of the people who built these ancient structures

Recent Examples on the Web

Greek Yogurt With Flaxseed and Prunes Yogurt with live cultures may help support gut bacteria, while ground flaxseed provides both soluble and insoluble fiber. — Sarah Jividen, Verywell Health, 23 July 2026

The seeds hold most of the insoluble fiber, and the skin adds even more, according to Martorano. — Olivia McIntosh, Martha Stewart, 22 July 2026

Many popular houseplants contain insoluble calcium oxalate crystals, tiny needle-like structures found in their leaves and stems. — Ryan Brennan, Fort Worth Star-Telegram, 14 July 2026

Word History

Etymology

Middle English insolible, from Latin insolubilis, from in- + solvere to free, dissolve — more at solve

First Known Use

14th century, in the meaning defined above

Rhymes for insoluble

• soluble
• voluble
• indissoluble
• revoluble

Kids Definition

insoluble

adjective

in·​sol·​u·​ble (ˈ)in-ˈsäl-yə-bəl 

1

: impossible to solve

an insoluble problem

2

: impossible or difficult to dissolve

a substance insoluble in water

Medical Definition

insoluble

adjective

in·​sol·​u·​ble (ˈ)in-ˈsäl-yə-bəl 

: incapable of being dissolved in a liquid

also : soluble only with difficulty or to a slight degree