\ˌin-ən(d)-ˈin \

Definition of in-and-in 

: in repeated generations of the same or closely related stock families … of one blood through mating or marrying in-and-in— F. H. Giddings in-and-in breeding

First Known Use of in-and-in

1765, in the meaning defined above

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The first known use of in-and-in was in 1765

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