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These included a small amount of muscle loss, increases in LDL and total cholesterol, and other reported issues such as possible nutritional deficiencies, gut microbiota changes, gastrointestinal symptoms, hyperuricemia, and (in some research) bone-health concerns.—Emily Kay Votruba, EverydayHealth.com, 3 Dec. 2025 The most common adverse reactions to the drug were upper respiratory infection, muscle spasms, hyperuricemia, back pain, abdominal pain or discomfort, bronchitis, pain in extremity, anemia and elevated liver enzymes.—Jen Christensen, CNN, 21 Feb. 2020 Reducing the hyperuricemia reduces the risk of another attack of gout.—Lisa Sanders, M.d., New York Times, 31 Aug. 2017