hormone replacement therapy

noun

: the therapeutic use of hormones typically to increase diminished levels in the body : hormone therapy

The usual treatment for hypothyroidism is hormone replacement therapy.

—Kate Murphy

especially : the administration of estrogen often along with a synthetic progestin especially to ameliorate the symptoms of menopause and reduce the risk of postmenopausal osteoporosis

—abbreviation HRT

Examples of hormone replacement therapy in a Sentence

Recent Examples on the Web

With the Food and Drug Administration’s (FDA) recent removal of the black box warning on hormone replacement therapy (HRT), also called menopause hormone therapy (MHT), more women may be interested in trying this class of medications. —Bonnie Vengrow, Flow Space, 6 Feb. 2026

For years, doctors prescribed hormone replacement therapy to relieve these symptoms, but for some people, the risk of side effects outweighs the benefit. —Bestreviews, Chicago Tribune, 4 Feb. 2026

They might first be prescribed antidepressants instead of hormone replacement therapy. —Laura Trujillo, USA Today, 3 Feb. 2026

Seeing as menopause can throw your hormones out of whack due to your ovaries decreasing the production of key hormones like estrogen and progesterone, Williams is also taking hormone replacement therapy (HRT) and recently started NAD+ injections. —Essence, 13 Jan. 2026

Word History

First Known Use

1945, in the meaning defined above

Rhymes for hormone replacement therapy

• brachytherapy
• chemotherapy
• cryotherapy
• hydrotherapy
• hypnotherapy
• monotherapy
• phototherapy
• psychotherapy
• sclerotherapy
• immunotherapy
• pharmacotherapy
• physiotherapy

Medical Definition

hormone replacement therapy

noun

: the therapeutic use of hormones typically to increase diminished levels in the body : hormone therapy

The usual treatment for hypothyroidism is hormone replacement therapy.

—Kate Murphy

especially : the administration of estrogen often along with a synthetic progestin especially to ameliorate the symptoms of menopause and reduce the risk of postmenopausal osteoporosis

—abbreviation HRT