glu·​ta·​mate | \ ˈglü-tə-ˌmāt How to pronounce glutamate (audio) \

Definition of glutamate

: a salt or ester of glutamic acid specifically : a salt or ester of levorotatory glutamic acid that functions as an excitatory neurotransmitter — compare monosodium glutamate

Examples of glutamate in a Sentence

Recent Examples on the Web When combining the amino acids L-glutamate and beta-alanine, Zoll typically dissolves the mixture in high-proof vodka and dries it on a hot plate. Joanna Thompson, Scientific American, 23 Mar. 2022 In fact, studies have shown that the levels of glutamate were increased in patients with insomnia. Lisa Bain, Good Housekeeping, 12 June 2022 However, ketamine seems to primarily impact a different brain chemical called glutamate, which helps stimulate brain cells to communicate. Raleigh Mcelvery, Smithsonian Magazine, 24 May 2022 Sometimes beta-alanine and L-glutamate form thicker, more textured crystals such as the ones pictured here. Joanna Thompson, Scientific American, 23 Mar. 2022 There is also a drug with a different mechanism called memantine, which works by regulating glutamate, a neurotransmitter that, in excess, may lead to brain cell death. Mariana Lenharo,, 13 Apr. 2022 This supports the idea that changes in synaptic plasticity underlie depression and by targeting glutamate, ketamine could be reversing those changes. Claudia López Lloreda, STAT, 17 Aug. 2021 Substantial amounts of free glutamate can be found in champagne due to the ageing process. Joanne Shurvell, Forbes, 26 Oct. 2021 In this regard, considerable evidence has demonstrated that the regulation of two receptors—AMPA and NMDA—on many neurons that respond to the neurotransmitter glutamate control changes in the tiny junctions, or synapses, between neurons. Husseini Manji, Scientific American, 14 Sep. 2021 See More

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'glutamate.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

First Known Use of glutamate

1876, in the meaning defined above

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Time Traveler for glutamate

Time Traveler

The first known use of glutamate was in 1876

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Dictionary Entries Near glutamate

glutaconic acid


glutamic acid

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Statistics for glutamate

Last Updated

15 Jul 2022

Cite this Entry

“Glutamate.” Dictionary, Merriam-Webster, Accessed 18 Aug. 2022.

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More Definitions for glutamate


glu·​ta·​mate | \ ˈglüt-ə-ˌmāt How to pronounce glutamate (audio) \

Medical Definition of glutamate

: a salt or ester of glutamic acid specifically : a salt or ester of levorotatory glutamic acid that functions as an excitatory neurotransmitter — see monosodium glutamate

More from Merriam-Webster on glutamate Encyclopedia article about glutamate


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