fetal hemoglobin

noun

Definition of fetal hemoglobin

: a hemoglobin variant that predominates in the blood of a newborn and persists in increased proportions in some forms of anemia (such as thalassemia)

Examples of fetal hemoglobin in a Sentence

Recent Examples on the Web For the sickle-cell patient, the fetal hemoglobin accounted for half her total a year after the procedure. John Timmer, Ars Technica, "A promising start to new human gene-editing trials," 9 Dec. 2020 One of the ideas that has been considered for treating these anemias is to reactivate the fetal hemoglobin gene. John Timmer, Ars Technica, "A promising start to new human gene-editing trials," 9 Dec. 2020 The results of the sickle cell trial showed the treatment proved effective in increasing the level of fetal hemoglobin while reducing the level of the sickle hemoglobin. Paul Adepoju, Quartz Africa, "Scientists have made big steps in using gene editing to cure sickle cell disease," 8 Dec. 2020 For example, reversing the fetal hemoglobin off switch, as the new CRISPR and RNA-based gene therapy strategies do, allows blood cells to make natural levels of the protein. Jocelyn Kaiser, Science | AAAS, "CRISPR and another genetic strategy fix cell defects in two common blood disorders," 5 Dec. 2020 Blood cells filled with fetal hemoglobin do not sickle. Gina Kolata, BostonGlobe.com, "At 16, she’s a pioneer in the fight to cure sickle cell disease," 11 Jan. 2020 Blood cells filled with fetal hemoglobin do not sickle. New York Times, "At 16, She’s a Pioneer in the Fight to Cure Sickle Cell Disease," 11 Jan. 2020 Normally fetal hemoglobin, which provides the developing fetus with oxygen via the blood while in utero, is shut off about six months after birth, and genes for adult hemoglobin are turned on. Time, "CRISPR Gene Editing Is Being Tested in Human Patients, and the Results Could Revolutionize Health Care," 6 Aug. 2019 This process involves removing premature cells from the bone marrow and modifying them -- using CRISPR in the lab -- to eventually produce fetal hemoglobin. Michael Nedelman And Minali Nigam, CNN, "Trial underway in US uses CRISPR gene-editing in people with severe sickle cell disease," 30 July 2019

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'fetal hemoglobin.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

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First Known Use of fetal hemoglobin

1950, in the meaning defined above

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The first known use of fetal hemoglobin was in 1950

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Last Updated

30 Dec 2020

Cite this Entry

“Fetal hemoglobin.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/fetal%20hemoglobin. Accessed 18 Jan. 2021.

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More Definitions for fetal hemoglobin

fetal hemoglobin

noun

Medical Definition of fetal hemoglobin

: hemoglobin that consists of two alpha chains and two gamma chains and that predominates in the blood of a newborn and persists in increased proportions in some forms of anemia (as thalassemia)

called also hemoglobin F

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