Definition of estrone
: a natural estrogenic hormone that is a ketone C18H22O2 found in the body chiefly as a metabolite of estradiol, that is also secreted especially by the ovaries, and that is used to treat various conditions (such as ovarian failure and menopausal symptoms) relating to estrogen deficiency
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Merriam-Webster unabridged
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Time Traveler for estrone
The first known use of estrone was in 1933
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