: the act of estranging or the condition of being estranged : alienation especially in friendship
the small difference of opinion snowballed into mutual resentment and resulted in final and total estrangement the hero, a middle-aged intellectual and student, has passed through successive estrangements from bourgeois life—
Time resulted in the almost complete estrangement of arts and letters from the sciences—
Scientific American Reader
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Merriam-Webster unabridged
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