epistasis

noun

epis·​ta·​sis i-ˈpi-stə-səs How to pronounce epistasis (audio)
plural epistases i-ˈpi-stə-ˌsēz How to pronounce epistasis (audio)
: suppression of the effect of a gene by a nonallelic gene
epistatic adjective

Examples of epistasis in a Sentence

Recent Examples on the Web
Examples are automatically compiled from online sources to show current usage. Read More Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback.
To put it differently, a full embrace of epistasis can feel almost nihilistic. C. Brandon Ogbunu, Quanta Magazine, 31 July 2023 The reason for outbreeding depression is most likely going to be some sort of antagonistic epistasis, deleterious gene-gene interactions. Razib Khan, Discover Magazine, 20 July 2012

Word History

Etymology

epi- + -stasis, after earlier epistatic, by analogy with metastatic : metastatis and like pairs

Note: The term epistatic was introduced, along with hypostatic, by the English biologist William Bateson (1861-1926) in "Facts Limiting the Theory of Heredity" ("Address delivered at the International Zoological Congress, before the Section of Cytology and Heredity, August 23, 1907"), Science, series 2, vol. 26 (July-December, 1907), issue of November 15, 1907, p. 653: "Till lately we spoke of the relations between the gray color of the mouse to the black color in terms of dominance …We can perhaps best express the relation between the gray and the black by the use of metaphor 'higher and lower,' and I therefore suggest the term epistatic as applicable to characters which have to be, as it were, lifted off in order to permit the lower or hypostatic character to appear."

First Known Use

circa 1917, in the meaning defined above

Time Traveler
The first known use of epistasis was circa 1917

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Cite this Entry

“Epistasis.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/epistasis. Accessed 10 Sep. 2025.

Medical Definition

epistasis

noun
epis·​ta·​sis i-ˈpis-tə-səs How to pronounce epistasis (audio)
plural epistases -ˌsēz How to pronounce epistasis (audio)
1
a
: suppression of a secretion or discharge
b
: a scum on the surface of urine
2
: suppression of the effect of a gene by a nonallelic gene
the role of epistasis in polygenic inheritance

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