epidermis

noun

epi·​der·​mis ˌe-pə-ˈdər-məs 

1

a

: the outer epithelial layer of the external integument of the animal body that is derived from the embryonic epiblast

specifically : the outer nonsensitive and nonvascular layer of the skin of a vertebrate that overlies the dermis

b

: any of various animal integuments

2

: a thin surface layer of tissue in higher plants formed by growth of a primary meristem

Did you know?

Epidermis includes the Greek prefix epi-, meaning "outer;" thus, the epidermis overlies the dermis, or inner layer of skin. The epidermis itself consists of four or five layers; the outermost layer is made of dead cells, which are being shed continuously. The epidermis acts as a physical barrier—a protective wrap over the body's surface, which, by preventing water loss, allows vertebrates to live on land.

Examples of epidermis in a Sentence

Recent Examples on the Web

The top layer acts as a protective outer covering, similar to the epidermis. —Kurt Knutsson, FOXNews.com, 12 Jan. 2026

The outermost layer of skin (epidermis) has been exfoliated, revealing newer, more sensitive layers underneath. —Essence, 8 Jan. 2026

Its anti-inflammatory action also strengthens the epidermis, helping prevent redness and flare-ups. —Alice Abbiadati, Vogue, 3 Jan. 2026

The outermost layer acts as a protective surface similar to human epidermis. —Neetika Walter, Interesting Engineering, 30 Dec. 2025

Word History

Etymology

Late Latin, from Greek, from epi- + derma skin — more at derm-

First Known Use

1626, in the meaning defined at sense 1a

Rhymes for epidermis

• endodermis
• hypodermis
• dermis
• thermos
• vermis

Kids Definition

epidermis

noun

epi·​der·​mis ˌep-ə-ˈdər-məs 

1

: the thin outer layer of the animal body that in vertebrates forms an insensitive covering over the dermis

2

: a thin surface layer of protecting cells in seed plants and ferns

Medical Definition

epidermis

noun

epi·​der·​mis -ˈdər-məs 

1

: the outer epithelial layer of the external integument of the animal body that is derived from the embryonic epiblast

specifically : the outer nonsensitive and nonvascular layer of the skin of a vertebrate that overlies the dermis

2

: any of various animal integuments