cystic fibrosis

noun

: a common, progressive hereditary disease of exocrine gland function that typically appears in infancy or early childhood and is marked by the accumulation of thick, sticky mucus in the ducts and passages of various organs and especially those of the lungs and pancreas resulting in shortness of breath, persistent cough, chronic respiratory infection, pancreatic enzyme insufficiency, faulty digestion, malnutrition, and poor growth

Note: The genetic mutation linked to cystic fibrosis causes disruption in the movement of chloride ions and water across cell membranes resulting in mucus that is thick and sticky instead of thin and slippery and in elevated concentrations of sodium and chloride in sweat and saliva. Cystic fibrosis occurs especially in people of northern European ancestry and is inherited as an autosomal recessive trait requiring that both parents pass on a copy of the defective gene on a chromosome other than a sex chromosome.

… children with cystic fibrosis are born with healthy lungs; only later do their lungs become plugged with mucus and incur infections.The Journal of the American Medical Association
Cystic fibrosis is the most common lethal inherited disorder in the United States. Approximately 30,000 people in this country have inherited two defective copies of the CF gene and thus the disease; approximately 1 in 20 Americans has just one copy of the gene and is a carrier of the disease.Joe Palca
abbreviation CF

Examples of cystic fibrosis in a Sentence

Recent Examples on the Web Others include retrograde ejaculation, in which semen travels backward into the body, and rarer conditions linked to cystic fibrosis. Marc Ramirez, USA TODAY, 16 June 2024 So, the researchers obtained lung cells from a volunteer who has cystic fibrosis, and cultured them in a way to form a three-dimensional tissue. John Timmer, Ars Technica, 13 June 2024 Misfolded proteins have the wrong shape and can cause illnesses such as neurodegenerative diseases, cystic fibrosis and Type 2 diabetes. Marc Zimmer, Discover Magazine, 10 June 2024 After a lifetime with cystic fibrosis, and 13 years battling an unconquerable infection, Mallory’s body could take no more. Tribune News Service, The Mercury News, 18 May 2024 See all Example Sentences for cystic fibrosis 

These examples are programmatically compiled from various online sources to illustrate current usage of the word 'cystic fibrosis.' Any opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback about these examples.

Word History

First Known Use

1938, in the meaning defined above

Time Traveler
The first known use of cystic fibrosis was in 1938

Dictionary Entries Near cystic fibrosis

Cite this Entry

“Cystic fibrosis.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/cystic%20fibrosis. Accessed 19 Jul. 2024.

Kids Definition

cystic fibrosis

noun
: an inherited disease marked by the buildup of thick sticky mucus chiefly in the lungs and pancreas leading to recurrent lung infections and digestive problems

Medical Definition

cystic fibrosis

noun
: a common, progressive, hereditary disease of exocrine gland function that typically appears in infancy or early childhood and is marked by the accumulation of thick, sticky mucus in the ducts and passages of various organs and especially those of the lungs and pancreas resulting in shortness of breath, persistent cough, chronic respiratory infection, pancreatic enzyme insufficiency, faulty digestion, malnutrition, and poor growth

Note: The genetic mutation linked to cystic fibrosis causes disruption in the movement of chloride ions and water across cell membranes resulting in mucus that is thick and sticky instead of thin and slippery and in elevated concentrations of sodium and chloride in sweat and saliva. Cystic fibrosis occurs especially in people of northern European ancestry and is inherited as an autosomal recessive trait requiring that both parents pass on a copy of the defective gene on a chromosome other than a sex chromosome.

called also fibrocystic disease of the pancreas, mucoviscidosis

abbreviation CF

More from Merriam-Webster on cystic fibrosis

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