cystic fibrosis

noun

Definition of cystic fibrosis

: a common, progressive hereditary disease of exocrine gland function that typically appears in infancy or early childhood and is marked by the accumulation of thick, sticky mucus in the ducts and passages of various organs and especially those of the lungs and pancreas resulting in shortness of breath, persistent cough, chronic respiratory infection, pancreatic enzyme insufficiency, faulty digestion, malnutrition, and poor growth

Note: The genetic mutation linked to cystic fibrosis causes disruption in the movement of chloride ions and water across cell membranes resulting in mucus that is thick and sticky instead of thin and slippery and in elevated concentrations of sodium and chloride in sweat and saliva. Cystic fibrosis occurs especially in people of northern European ancestry and is inherited as an autosomal recessive trait requiring that both parents pass on a copy of the defective gene on a chromosome other than a sex chromosome.

… children with cystic fibrosis are born with healthy lungs; only later do their lungs become plugged with mucus and incur infections.The Journal of the American Medical Association Cystic fibrosis is the most common lethal inherited disorder in the United States. Approximately 30,000 people in this country have inherited two defective copies of the CF gene and thus the disease; approximately 1 in 20 Americans has just one copy of the gene and is a carrier of the disease.— Joe Palca abbreviation CF

Examples of cystic fibrosis in a Sentence

Recent Examples on the Web Jay Gironimi, a Groton resident who has cystic fibrosis, said prescription medication is miraculous, but increasingly costly, at thousands of dollars a month. Stephen Singer, courant.com, "Gov. Lamont and Gov. Baker want to penalize pharma companies with steep price increases for prescription drugs," 6 Apr. 2021 Those with severe lung disease, including asthma requiring hospitalization within the past year and cystic fibrosis. Jessie Balmert, The Enquirer, "COVID-19 vaccines in Ohio: DeWine authorizes providers to fill appointment slots with anyone 16+," 22 Mar. 2021 Companies are working to find ways to use mRNA for flu vaccines, as well as treatments for heart failure and cystic fibrosis. Robert Langreth, Fortune, "Moderna vaccine cleared in U.S., boosting immunization effort," 19 Dec. 2020 Haley plays 17-year-old Stella who has cystic fibrosis, a condition that means the body produces thick mucus that can block air to the lungs. Kori Williams, Seventeen, "50 Best Romantic Movies of All Time to Stream Now," 9 Mar. 2021 Those conditions include asthma, cystic fibrosis, liver disease, high blood pressure and BMI over 25 — meaning, for example, a person who is 5 feet 6 inches tall and weighs more than 155 pounds, or is 6 feet tall and weighs more than 184 pounds. Washington Post, "All overweight D.C. residents will get priority for the coronavirus vaccine. Experts are skeptical.," 21 Jan. 2021 The company’s other cystic fibrosis drugs may also win approval for treating younger children and patients with additional genetic mutations, giving it a clear growth runway for years to come. Dallas News, "Motley Fool: Vertex Pharma’s drug pipeline looks promising," 13 Dec. 2020 Joshua Hillman, a Harvard Law School student from Prattville who was born with cystic fibrosis, a genetic, life-threatening lung disease without a cure, said he was frequently hospitalized in high school before the ACA was passed. Howard Koplowitz | Hkoplowitz@al.com, al, "Jones, Alabamians with preexisting conditions warn of consequences if Obamacare struck down," 16 Oct. 2020 Pierce set out to become a respiratory therapist like the ones who had helped her through the years, and her experience with cystic fibrosis helps her soothe patients who are struggling for air. Dana Branham, Dallas News, "Dallas respiratory therapist commits to helping patients, even as cystic fibrosis puts her at risk," 3 Jan. 2021

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'cystic fibrosis.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

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First Known Use of cystic fibrosis

1938, in the meaning defined above

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The first known use of cystic fibrosis was in 1938

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Statistics for cystic fibrosis

Last Updated

11 Apr 2021

Cite this Entry

“Cystic fibrosis.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/cystic%20fibrosis. Accessed 13 Apr. 2021.

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More Definitions for cystic fibrosis

cystic fibrosis

noun

English Language Learners Definition of cystic fibrosis

medical : a very serious disease that usually appears in young children and that makes it hard to breathe and to digest food properly

cystic fibrosis

noun

Medical Definition of cystic fibrosis

: a common, progressive, hereditary disease of exocrine gland function that typically appears in infancy or early childhood and is marked by the accumulation of thick, sticky mucus in the ducts and passages of various organs and especially those of the lungs and pancreas resulting in shortness of breath, persistent cough, chronic respiratory infection, pancreatic enzyme insufficiency, faulty digestion, malnutrition, and poor growth

Note: The genetic mutation linked to cystic fibrosis causes disruption in the movement of chloride ions and water across cell membranes resulting in mucus that is thick and sticky instead of thin and slippery and in elevated concentrations of sodium and chloride in sweat and saliva. Cystic fibrosis occurs especially in people of northern European ancestry and is inherited as an autosomal recessive trait requiring that both parents pass on a copy of the defective gene on a chromosome other than a sex chromosome.

called also fibrocystic disease of the pancreas, mucoviscidosis

abbreviation CF

More from Merriam-Webster on cystic fibrosis

Britannica.com: Encyclopedia article about cystic fibrosis

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