clo·​ni·​dine ˈklä-nə-ˌdēn How to pronounce clonidine (audio) ˈklō- How to pronounce clonidine (audio)
: an antihypertensive drug C9H9Cl2N3 used especially to treat essential hypertension, to prevent migraine headache, and to diminish opioid and nicotine withdrawal symptoms

Examples of clonidine in a Sentence

Recent Examples on the Web Among the options: hormone replacement therapy, low-dose selective serotonin reuptake inhibitors (SSRIs), gabapentin, clonidine, and fezolinetant. Angela Haupt, TIME, 21 June 2024 Some case studies indicate that kratom may have mechanisms similar to opioid withdrawal treatments like clonidine. Claire Bugos, Verywell Health, 3 Aug. 2023 Hormone therapy, clonidine pills or patches, low-dose antidepressants, and vaginal estrogen are among some of the treatments, per the Mayo Clinic, yet experts say many people don’t know about the benefits or drawbacks of treatment. Alexa Mikhail, Fortune, 1 Feb. 2023 My blood pressure still fluctuated, and I was prescribed 5 mg of clonidine to take as emergency medication for anything over 180/100. Dr. Keith Roach, oregonlive, 1 July 2022 Medication options for opioids include methadone, buprenorphine, naltrexone, or clonidine. Sara Lindberg, SELF, 1 Nov. 2021 Our treatment of cPTSD is with mood stabilizers, like Prozac, and drugs that block the action of adrenaline-type neurotransmitters, like clonidine, and some dogs show acceptable or even good improvement. Gareth Cook, Scientific American, 6 Sep. 2016 Although non-prescription melatonin is by far the most popular, some children are prescribed epilepsy drugs, sedatives, alpha agonists such as clonidine or antidepressants such as trazodone, depending on the nature of their problem. Claudia Wallis, Scientific American, 18 Nov. 2017 Medication therapy may include the blood pressure medicine clonidine, which is safe if used cautiously under supervision. Dr. Keith Roach, oregonlive, 31 May 2021

These examples are programmatically compiled from various online sources to illustrate current usage of the word 'clonidine.' Any opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback about these examples.

Word History


chlor- + aniline + imide + -ine entry 2

First Known Use

1969, in the meaning defined above

Time Traveler
The first known use of clonidine was in 1969

Dictionary Entries Near clonidine

Cite this Entry

“Clonidine.” Dictionary, Merriam-Webster, Accessed 24 Jul. 2024.

Medical Definition


clo·​ni·​dine ˈklän-ə-ˌdēn How to pronounce clonidine (audio) ˈklōn- How to pronounce clonidine (audio)
: an antihypertensive drug used in the form of its hydrochloride C9H9Cl2N3·HCl especially to treat essential hypertension, to prevent migraine headache, and to diminish opiate withdrawal symptoms

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