ceramide

noun

cer·​amide ˈsir-ə-ˌmīd 

ˈser-

plural ceramides

: any of various simple sphingolipids that are composed of a fatty acid linked to sphingosine, are found especially in cell membranes, are involved in mediating various cellular processes (such as those affecting cell differentiation and apoptosis), and act as precursors for more complex sphingolipids

The enzyme controls production of a cellular substance, ceramide, which triggers the natural process of egg cell death.

—L. Stivitz

Moisturizers containing ceramides (natural lipids that are similar in structure to those in the skin's own moisture barrier) … are also worthwhile splurges for women with dry or problem skin, according to independent tester Grove.

—Constance Cardozo

Examples of ceramide in a Sentence

Recent Examples on the Web

This longer-lasting formula is made with aluminum, botanical scents like cucumber and pear, and ceramides—the trifecta for hardworking armpits. —Sara Coughlin, SELF, 23 July 2025

In addition to sun-protecting minerals, the formula contains hyaluronic acid and three different ceramides, which help moisturize and support the skin’s natural barrier. —Brigitt Earley, Glamour, 23 July 2025

Hyaluronic acid, ceramides, niacinamide, peptides, and panthenol to repair the skin barrier and add moisture. —Larry Stansbury, Essence, 14 July 2025

The emphasis isn’t just on styling but on truly restoring scalp and strand health with ingredients often found in skincare—think collagen, ceramides, and botanical oils. —Conçetta Ciarlo, Vogue, 11 July 2025

Word History

Etymology

cerebroside + amide

First Known Use

1958, in the meaning defined above

Rhymes for ceramide

• actinide
• aldehyde
• alkoxide
• alongside
• amplified
• arsenide
• beautified
• biocide
• butoxide
• calcified
• certified
• citywide

Medical Definition

ceramide

noun

cer·​amide ˈsir-ə-ˌmīd 

: any of a group of amido sphingolipids formed by linking a fatty acid to sphingosine and found widely in small amounts in plant and animal tissue