ceramide

noun

cer·​amide ˈsir-ə-ˌmīd 

ˈser-

plural ceramides

: any of various simple sphingolipids that are composed of a fatty acid linked to sphingosine, are found especially in cell membranes, are involved in mediating various cellular processes (such as those affecting cell differentiation and apoptosis), and act as precursors for more complex sphingolipids

The enzyme controls production of a cellular substance, ceramide, which triggers the natural process of egg cell death.

—L. Stivitz

Moisturizers containing ceramides (natural lipids that are similar in structure to those in the skin's own moisture barrier) … are also worthwhile splurges for women with dry or problem skin, according to independent tester Grove.

—Constance Cardozo

Examples of ceramide in a Sentence

Recent Examples on the Web

That ratio speaks to a blend of 2% ceramides, 4% cholesterol, 2% fatty acids. —Conçetta Ciarlo, Vogue, 27 Jan. 2026

These pre-soaked pads pair pore-clearing salicylic acid with a gentle dose of texture-refining retinol, while cica and green tea ceramide from Korea’s mineral-rich Jeju Island soothe and calm skin. —Sarah Han, Allure, 27 Jan. 2026

The best barrier repair creams have equal parts cholesterol, ceramides and fatty acids to mimic the skin’s natural lipid structure. —Leslie Baumann, Miami Herald, 23 Jan. 2026

This spray is incredibly refreshing — peppermint oil and menthol give an instant cool, while honey and ceramides help keep the scalp moisturized and balanced. —Jacqueline Kilikita, Refinery29, 22 Jan. 2026

Word History

Etymology

cerebroside + amide

First Known Use

1958, in the meaning defined above

Rhymes for ceramide

• actinide
• aldehyde
• alkoxide
• alongside
• amplified
• arsenide
• beautified
• biocide
• butoxide
• calcified
• certified
• citywide

Medical Definition

ceramide

noun

cer·​amide ˈsir-ə-ˌmīd 

: any of a group of amido sphingolipids formed by linking a fatty acid to sphingosine and found widely in small amounts in plant and animal tissue