ceramide

noun

cer·​amide ˈsir-ə-ˌmīd 

ˈser-

plural ceramides

: any of various simple sphingolipids that are composed of a fatty acid linked to sphingosine, are found especially in cell membranes, are involved in mediating various cellular processes (such as those affecting cell differentiation and apoptosis), and act as precursors for more complex sphingolipids

The enzyme controls production of a cellular substance, ceramide, which triggers the natural process of egg cell death.

—L. Stivitz

Moisturizers containing ceramides (natural lipids that are similar in structure to those in the skin's own moisture barrier) … are also worthwhile splurges for women with dry or problem skin, according to independent tester Grove.

—Constance Cardozo

Examples of ceramide in a Sentence

Recent Examples on the Web

That’s thanks in part to the combination of humectants (hyaluronic acid, in five molecular weights, and polyglutamic acid) and moisture-sealing lipids (murumuru butter and ceramides). —Deanna Pai, Vogue, 27 Nov. 2025

Squalane for lightweight emollience, ceramides to help maintain a strong, healthy barrier, and ectoin to support long-lasting moisture retention. —Christa Joanna Lee, Allure, 24 Nov. 2025

Hydrating skincare ingredients such as ceramides, peptides, hyaluronic acid, and antioxidants can help smooth the skin's surface and improve wear time. —Grace McCarty, Glamour, 21 Nov. 2025

Look for formulas that have hydrating ingredients like hyaluronic acid, glycerin, or ceramides. —Iona Brannon, Travel + Leisure, 2 Nov. 2025

Word History

Etymology

cerebroside + amide

First Known Use

1958, in the meaning defined above

Rhymes for ceramide

• actinide
• aldehyde
• alkoxide
• alongside
• amplified
• arsenide
• beautified
• biocide
• butoxide
• calcified
• certified
• citywide

Medical Definition

ceramide

noun

cer·​amide ˈsir-ə-ˌmīd 

: any of a group of amido sphingolipids formed by linking a fatty acid to sphingosine and found widely in small amounts in plant and animal tissue