ceramide

noun

cer·​amide ˈsir-ə-ˌmīd 

ˈser-

plural ceramides

: any of various simple sphingolipids that are composed of a fatty acid linked to sphingosine, are found especially in cell membranes, are involved in mediating various cellular processes (such as those affecting cell differentiation and apoptosis), and act as precursors for more complex sphingolipids

The enzyme controls production of a cellular substance, ceramide, which triggers the natural process of egg cell death.

—L. Stivitz

Moisturizers containing ceramides (natural lipids that are similar in structure to those in the skin's own moisture barrier) … are also worthwhile splurges for women with dry or problem skin, according to independent tester Grove.

—Constance Cardozo

Examples of ceramide in a Sentence

Recent Examples on the Web

Focus on barrier repair overnight and look for ceramides, fatty acids and cholesterol. —Fort Worth Star-Telegram, 9 Apr. 2026

The long-lasting formula includes ceramides and ULTRAPLEX, which promote a stronger skin barrier and help seal in moisture. —Bestreviews, Chicago Tribune, 9 Apr. 2026

Look for key ingredients like ceramides, which repair the skin barrier; peptides, which support firmness; and squalane, which provides lightweight hydration. —Kansas City Star, 8 Apr. 2026

Shop the Goop Youth Booth Peptide Cream, plus similar peptide- and ceramide-rich creams, below. —Kaitlin Clapinski, InStyle, 7 Apr. 2026

Word History

Etymology

cerebroside + amide

First Known Use

1958, in the meaning defined above

Rhymes for ceramide

• actinide
• aldehyde
• alkoxide
• alongside
• amplified
• arsenide
• beautified
• biocide
• butoxide
• calcified
• certified
• citywide

Medical Definition

ceramide

noun

cer·​amide ˈsir-ə-ˌmīd 

: any of a group of amido sphingolipids formed by linking a fatty acid to sphingosine and found widely in small amounts in plant and animal tissue