blood-brain barrier

noun
\ ˈbləd-ˈbrān- How to pronounce blood-brain barrier (audio) \

Definition of blood-brain barrier

: a naturally occurring barrier created by the modification of brain capillaries (as by reduction in fenestration and formation of tight cell-to-cell contacts) that prevents many substances from leaving the blood and crossing the capillary walls into the brain tissues

Examples of blood-brain barrier in a Sentence

Recent Examples on the Web In some people, the novel coronavirus, also known as SARS-CoV-2, triggers a huge release of inflammation signals leading to blood-brain barrier dysfunction, which can promote neuroinflammation and brain cell death. Washington Post, "Large-scale global study to investigate links between covid-19 and cognitive decline," 5 Jan. 2021 Fish exposed to plastic nanoparticles ended up with brain damage after the particles crossed the blood-brain barrier, a sort of biological force field meant to keep nasties like pathogens out. Matt Simon, Wired, "Babies May Be Drinking Millions of Microplastic Particles a Day," 19 Oct. 2020 In some extreme cases, an intense immune response known as a cytokine storm that can occur in response to COVID-19 may penetrate the blood-brain barrier. Sara Kiley Watson, Popular Science, "These COVID symptoms could last for months," 22 Sep. 2020 The blood-brain barrier, which protects the organ from harmful substances, complicates the delivery of any potentially therapeutic compound. Lydia Denworth, Science | AAAS, "Is gene therapy ready to treat some forms of autism?," 14 Oct. 2020 These cytokines are seemingly able to cross the semipermeable network of capillaries that connect the brain to the rest of the body (known as the blood-brain barrier). Claire Maldarelli, Popular Science, "An exhaustive account of how the flu destroys your body," 22 Feb. 2018 Their work focuses on what chemicals make it past the blood-brain barrier if inhaled or ingested, said Indiana University clinical pharmacology professor Robert Stratford. Meredith Colias-pete, chicagotribune.com, "With EPA grant, Indiana researchers to study how toxins seep into brain," 14 Aug. 2020 Too much inflammation can also break down the protective wall known as the blood-brain barrier and lead to brain swelling, seizures or spread of infection. Dr. Minali Nigam And Dr. Sanjay Gupta, CNN, "We're only just beginning to learn how Covid-19 affects the brain," 29 July 2020 So is the blood-brain barrier sampled during a COVID-19 nasal swab? Miriam Fauzia, USA TODAY, "Fact check: No, the COVID-19 nasal test doesn't swab the blood-brain barrier," 9 July 2020

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'blood-brain barrier.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

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First Known Use of blood-brain barrier

1934, in the meaning defined above

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Time Traveler for blood-brain barrier

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The first known use of blood-brain barrier was in 1934

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Last Updated

19 Jan 2021

Cite this Entry

“Blood-brain barrier.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/blood-brain%20barrier. Accessed 23 Jan. 2021.

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More Definitions for blood-brain barrier

blood-brain barrier

noun

Medical Definition of blood-brain barrier

: a naturally occurring barrier created by the modification of brain capillaries (as by reduction in fenestration and formation of tight cell-to-cell contacts) that prevents many substances from leaving the blood and crossing the capillary walls into the brain tissues abbreviation BBB

More from Merriam-Webster on blood-brain barrier

Britannica.com: Encyclopedia article about blood-brain barrier

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