blood-brain barrier

noun
\ˈbləd-ˈbrān- \

Definition of blood-brain barrier 

: a naturally occurring barrier created by the modification of brain capillaries (as by reduction in fenestration and formation of tight cell-to-cell contacts) that prevents many substances from leaving the blood and crossing the capillary walls into the brain tissues

Examples of blood-brain barrier in a Sentence

Recent Examples on the Web

In children, particularly those under the age of 10 or babies in the womb, the metal can pass through the blood-brain barrier and kill off brain cells. Julia Belluz, Vox, "The Trump administration’s attack on children’s health protections," 27 Sep. 2018 Then again, the explanation could be more simple: Chemotherapies designed to kill certain cells are breaching the blood-brain barrier and attacking neurons directly. Melissa Healy, Washington Post, "The story must be told.," 16 June 2018 Some researchers, however, still argue that the CGRP-blocking antibodies must be getting past the blood-brain barrier into the brainstem—even in trace amounts—to be effective. Emily Underwood, Science | AAAS, "Will antibodies finally put an end to migraines?," 18 May 2018 In that case, the pathogens would be opportunistic, not causal, sneaking across the blood-brain barrier and taking up residence only after Alzheimer’s has developed. Sharon Begley, STAT, "New study supports long-dismissed idea: Herpes viruses could play role in Alzheimer’s," 21 June 2018 Then again, the explanation could be more simple: Chemotherapies designed to kill certain cells are breaching the blood-brain barrier and attacking neurons directly. Melissa Healy, latimes.com, "What causes ‘chemobrain’? It’s time for neuroscientists to get serious about finding out, experts say," 13 June 2018 In young people, the brain remains largely isolated from that inflammation, but with older people, our blood-brain barrier becomes kind of leaky. Judith Graham, Washington Post, "Surgery can cause cognitive losses in some seniors," 19 May 2018 Shire Pharmaceuticals has developed a therapy for the disease and has even found a way to deliver it across the blood-brain barrier, which is no mean feat. Vibhav Rangarajan, STAT, "The ‘cruel joke’ of compassionate use and right to try: Pharma companies don’t have to comply," 5 June 2018 In young people, the brain remains largely isolated from that inflammation, but with older people, our blood-brain barrier becomes kind of leaky. Judith Graham, Washington Post, "Surgery can cause cognitive losses in some seniors," 19 May 2018

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'blood-brain barrier.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

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First Known Use of blood-brain barrier

1934, in the meaning defined above

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Last Updated

15 Nov 2018

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Time Traveler for blood-brain barrier

The first known use of blood-brain barrier was in 1934

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More Definitions for blood-brain barrier

blood-brain barrier

noun

Medical Definition of blood-brain barrier 

: a naturally occurring barrier created by the modification of brain capillaries (as by reduction in fenestration and formation of tight cell-to-cell contacts) that prevents many substances from leaving the blood and crossing the capillary walls into the brain tissues abbreviation BBB

More from Merriam-Webster on blood-brain barrier

Rhyming Dictionary: Words that rhyme with blood-brain barrier

Britannica.com: Encyclopedia article about blood-brain barrier

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