blood-brain barrier

noun

: a naturally occurring barrier created by the modification of brain capillaries (as by reduction in fenestration and formation of tight cell-to-cell contacts) that prevents many substances from leaving the blood and crossing the capillary walls into the brain tissues

Examples of blood-brain barrier in a Sentence

Recent Examples on the Web Still, Jafari suspects that the problem is a result of a massive inflammatory reaction in the body that crosses the blood-brain barrier. Avery Hurt, Discover Magazine, 21 Mar. 2024 This unique combination provides a magnesium form that has a higher ability to cross the blood-brain barrier. Britannay Scanniello, Verywell Health, 1 Mar. 2024 That’s because Benadryl contains diphenhydramine HCl, a first-generation antihistamine that crosses the blood-brain barrier. Laura Lu, Ms, Parents, 29 Feb. 2024 What leukotriene modifiers such as Singulair are not supposed to do is cross the blood-brain barrier. Joanna Thompson, Scientific American, 19 Jan. 2024 Then, the ultrasound device agitates the bubbles with sound waves, creating gaps in the blood-brain barrier. Lizzy Lawrence, STAT, 12 May 2023 But research suggests the chemical may cross the blood-brain barrier in a manner that triggers Parkinson’s disease, a progressive, neurodegenerative disorder that affects movement. Hayley Smith, Los Angeles Times, 20 Dec. 2023 Meanwhile, injured blood vessels compromise the sacred blood-brain barrier that normally protects sensitive neural tissue from irritating molecules flowing through the rest of the body. Celia Ford, WIRED, 12 Sep. 2023 This is also the first study that shows how quickly the blood-brain barrier closes after being opened by the ultrasound. Laura Baisas, Popular Science, 3 May 2023

These examples are programmatically compiled from various online sources to illustrate current usage of the word 'blood-brain barrier.' Any opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback about these examples.

Word History

First Known Use

1934, in the meaning defined above

Time Traveler
The first known use of blood-brain barrier was in 1934

Dictionary Entries Near blood-brain barrier

Cite this Entry

“Blood-brain barrier.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/blood-brain%20barrier. Accessed 24 Apr. 2024.

Medical Definition

blood-brain barrier

noun
: a naturally occurring barrier created by the modification of brain capillaries (as by reduction in fenestration and formation of tight cell-to-cell contacts) that prevents many substances from leaving the blood and crossing the capillary walls into the brain tissues
abbreviation BBB

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