binding site


plural binding sites
: a location on a molecule or cell surface at which a chemical substance (such as an element or molecule) can bind (see bind entry 1 sense 5b)
A ligand is a molecule or ion whose shape is complementary to the shape of a binding site on a particular protein molecule.Gary A. Thibodeau
… the most favorable binding site of atomic antimony is the terminal carbon …Zhenjun Song et al.
The main calcium binding site within each monomer involves the main chain oxygen atom …Brian A. Fox et al.

Note: A binding site may demonstrate specificity for a particular chemical substance.

Examples of binding site in a Sentence

Recent Examples on the Web The small molecule drugs bind to the protein binding site and modulate its activity, thereby influencing the disease path. Marc Zimmer, Discover Magazine, 10 June 2024 Rather, transcription factors, their DNA binding sites, and other regulatory molecules may assemble into dense gatherings that exert their influence collectively. Philip Ball, Quanta Magazine, 14 Feb. 2024

These examples are programmatically compiled from various online sources to illustrate current usage of the word 'binding site.' Any opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback about these examples.

Word History

First Known Use

1950, in the meaning defined above

Time Traveler
The first known use of binding site was in 1950

Dictionary Entries Near binding site

Cite this Entry

“Binding site.” Dictionary, Merriam-Webster, Accessed 15 Jul. 2024.

Medical Definition

binding site

: a region on a molecule or cell surface at which the combining of chemical substances takes place
Proteins called transcription factors bind to these short DNA strings—transcription factor binding sites—to regulate the production of messenger RNA and thus the synthesis of proteins.Leonid Kruglyak and David L. Stern, Science
Last Updated: - Updated example sentences
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