antigen-presenting cell

noun
an·​ti·​gen-pre·​sent·​ing cell | \ ˈan-ti-jən-pri-ˈzen-tiŋ- How to pronounce antigen-presenting cell (audio) , -ˌjen- \
plural antigen-presenting cells

Definition of antigen-presenting cell

: any of various cells (such as a dendritic cell, macrophage, or B cell) that take up and process an antigen into a peptide fragment which when displayed at the cell surface in combination with a molecule of the major histocompatibility complex is recognized by and serves to activate cells of the immune system (such as helper T cells or cytotoxic T cells) His images showed interactions between immune cells called antigen-presenting cells (APCs) that specialize in breaking up proteins belonging to an invader, such as a virus, and displaying the protein fragments to T cells, which become activated when they recognize one of the antigens.— Daniel M. Davis antigen-presenting cells also display fragments of proteins derived from the body's own cells. In this case, the antigen-presenting cells train the T cells to ignore healthy cells that are part of the body.— Denise Faustman abbreviation APC

First Known Use of antigen-presenting cell

1975, in the meaning defined above

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The first known use of antigen-presenting cell was in 1975

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Cite this Entry

“Antigen-presenting cell.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/antigen-presenting%20cell. Accessed 24 Feb. 2021.

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antigen-presenting cell

noun

Medical Definition of antigen-presenting cell

: any of various cells (as a dendritic cell, macrophage, or B cell) that take up and process an antigen into a peptide fragment which when displayed at the cell surface in combination with histocompatibility antigen is recognized by and serves to activate cells of the immune system (as helper T cells or cytotoxic T cells) In contrast to antibody molecules, which can bind to antigens in solution, T cell receptors recognize antigen only when it is displayed on the surface of an antigen-presenting cell in association with a major histocompatibility complex (MHC) antigen.Scientific American Medicine Bulletin abbreviation APC

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