androgen insensitivity syndrome

noun
Updated on: 11 Apr 2018

Definition of androgen insensitivity syndrome

: a genetic disorder that causes complete or partial insensitivity to androgens in the body
Note: A person affected with androgen insensitivity syndrome has the physical appearance of a female and the X and Y chromosomes of a male with external genitalia that are female or ambiguous, no uterus, and usually normal but undescended testes. Androgen insensitivity syndrome is inherited as an X-linked recessive trait requiring that only one parent pass on a copy of the defective gene on an X chromosome to male offspring.
called also testicular feminization, testicular feminization syndrome

Recent Examples of androgen insensitivity syndrome from the Web

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First Known Use of androgen insensitivity syndrome

1978

in the meaning defined above

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Medical Dictionary

androgen insensitivity syndrome

noun

medical Definition of androgen insensitivity syndrome

: a genetic disorder that causes complete or partial insensitivity to androgens in the body
Note: A person affected with androgen insensitivity syndrome has the physical appearance of a female and the X and Y chromosomes of a male with external genitalia that are female or ambiguous, no uterus, and usually normal but undescended testes. Androgen insensitivity syndrome is inherited as an X-linked recessive trait requiring that only one parent pass on a copy of the defective gene on an X chromosome to male offspring.
  • If a chromosomally male embryo has androgen-insensitivity syndrome, … the cells' receptors for testosterone, an androgen, are deaf to the testosterone's instructions, and will thus develop the default external sexual characteristics of a female.
  • —Ariel LevyThe New Yorker30 Nov. 2009
called also testicular feminization, testicular feminization syndrome

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