androgen insensitivity syndrome

noun

: a genetic disorder that causes complete or partial insensitivity to androgens in the body

Note: A person affected with androgen insensitivity syndrome has the physical appearance of a female and the X and Y chromosomes of a male with external genitalia that are female or ambiguous, no uterus, and usually normal but undescended testes. Androgen insensitivity syndrome is inherited as an X-linked recessive trait requiring that only one parent pass on a copy of the defective gene on an X chromosome to male offspring.

called also testicular feminization, testicular feminization syndrome

Examples of androgen insensitivity syndrome in a Sentence

Recent Examples on the Web My post actually linked to androgen insensitivity syndrome. Razib Khan, Discover Magazine, 24 June 2012 Sean Saifa Wall is an intersex activist and researcher who was born with an intersex variation called androgen insensitivity syndrome, which occurs when a person who has XY chromosomes is resistant to hormones called androgens. Meghan McDonough, Scientific American, 24 Aug. 2022 Two of his nine siblings had undergone similar operations, but his relatives never talked about the fact that androgen insensitivity syndrome, a genetic intersex condition, ran in the family. Kate Sosin, USA TODAY, 11 Aug. 2020 She was born with androgen insensitivity syndrome, a condition that caused her to have external female anatomy and, internally, undescended testes instead of a uterus. Diane Stopyra, Marie Claire, 5 July 2017

These examples are programmatically compiled from various online sources to illustrate current usage of the word 'androgen insensitivity syndrome.' Any opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback about these examples.

Word History

First Known Use

1969, in the meaning defined above

Time Traveler
The first known use of androgen insensitivity syndrome was in 1969

Dictionary Entries Near androgen insensitivity syndrome

androgenesis

androgen insensitivity syndrome

androgeny

Cite this Entry

“Androgen insensitivity syndrome.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/androgen%20insensitivity%20syndrome. Accessed 22 May. 2024.

Medical Definition

androgen insensitivity syndrome

noun
: a genetic disorder that causes complete or partial insensitivity to androgens in the body

Note: A person affected with androgen insensitivity syndrome has the physical appearance of a female and the X and Y chromosomes of a male with external genitalia that are female or ambiguous, no uterus, and usually normal but undescended testes. Androgen insensitivity syndrome is inherited as an X-linked recessive trait requiring that only one parent pass on a copy of the defective gene on an X chromosome to male offspring.

If a chromosomally male embryo has androgen-insensitivity syndrome, … the cells' receptors for testosterone, an androgen, are deaf to the testosterone's instructions, and will thus develop the default external sexual characteristics of a female.Ariel Levy, The New Yorker

called also testicular feminization, testicular feminization syndrome

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