androgen insensitivity syndrome

noun

Definition of androgen insensitivity syndrome

: a genetic disorder that causes complete or partial insensitivity to androgens in the body
Note: A person affected with androgen insensitivity syndrome has the physical appearance of a female and the X and Y chromosomes of a male with external genitalia that are female or ambiguous, no uterus, and usually normal but undescended testes. Androgen insensitivity syndrome is inherited as an X-linked recessive trait requiring that only one parent pass on a copy of the defective gene on an X chromosome to male offspring.
called also testicular feminization, testicular feminization syndrome

First Known Use of androgen insensitivity syndrome

1978


Medical Dictionary

androgen insensitivity syndrome

noun

medical Definition of androgen insensitivity syndrome

: a genetic disorder that causes complete or partial insensitivity to androgens in the body
Note: A person affected with androgen insensitivity syndrome has the physical appearance of a female and the X and Y chromosomes of a male with external genitalia that are female or ambiguous, no uterus, and usually normal but undescended testes. Androgen insensitivity syndrome is inherited as an X-linked recessive trait requiring that only one parent pass on a copy of the defective gene on an X chromosome to male offspring.
  • If a chromosomally male embryo has androgen-insensitivity syndrome, … the cells' receptors for testosterone, an androgen, are deaf to the testosterone's instructions, and will thus develop the default external sexual characteristics of a female.
  • —Ariel LevyThe New Yorker30 Nov. 2009
called also testicular feminization, testicular feminization syndrome

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