amyotrophic lateral sclerosis

noun

amyo·​tro·​phic lateral sclerosis ˌā-ˌmī-ə-ˈtrō-fik-  -ˈträ- 

: a rare progressive degenerative fatal disease affecting the motor neurons, usually beginning in middle age, and characterized especially by increasing and spreading muscular weakness and atrophy

—abbreviation ALS

called also Lou Gehrig's disease

Examples of amyotrophic lateral sclerosis in a Sentence

Recent Examples on the Web

But interest in the nascent field is rising as companies notch up milestones, such as enabling people with degenerative conditions including amyotrophic lateral sclerosis (ALS) to type or play video games using brain signals. — Elaine Yu, CNBC, 11 July 2026

The technology was developed and tested in close collaboration with a person living with amyotrophic lateral sclerosis (ALS), a progressive neurological disease that gradually destroys the nerve cells controlling voluntary muscle movement. — Jijo Malayil, Interesting Engineering, 7 July 2026

Chris Johnson, the former NFL running back who holds the record for most yards from scrimmage in a single season, has the degenerative neurological disorder amyotrophic lateral sclerosis, commonly known as ALS or Lou Gehrig’s disease. — Chuck Schilken, Los Angeles Times, 29 June 2026

The Euphoria star, who died at 53 years old, 10 months after revealing his amyotrophic lateral sclerosis (ALS) diagnosis. — Kayla Grant, PEOPLE, 22 June 2026

Word History

Etymology

translation of French sclérose latérale amyotrophique; amyotrophique "marked by atrophy of a muscle" from a- a- entry 2 + myo- myo- + -trophique -trophic

First Known Use

1875, in the meaning defined above

Rhymes for amyotrophic lateral sclerosis

• acanthosis
• acidosis
• alkalosis
• amaurosis
• ankylosis
• asbestosis
• brucellosis
• cyanosis
• dermatosis
• diagnosis
• ecchymosis
• exostosis

Medical Definition

amyotrophic lateral sclerosis

noun

: a rare fatal progressive degenerative disease that affects pyramidal motor neurons, usually begins in middle age, and is characterized especially by increasing and spreading muscular weakness

—abbreviation ALS

called also Lou Gehrig's disease