am·​i·​trip·​ty·​line | \ ˌa-mə-ˈtrip-tə-ˌlēn How to pronounce amitriptyline (audio) \

Definition of amitriptyline

: a tricyclic aromatic antidepressant drug used in the form of its hydrochloride C20H23N·HCl to prevent migraines and to treat neuropathic pain, bulimia, and depression

Examples of amitriptyline in a Sentence

Recent Examples on the Web Antidepressants – Drugs like amitriptyline may be prescribed to shingles patients to alleviate postherpetic neuralgia., "What Is Shingles?," 1 May 2017 There's no specific treatment, and results vary from patient to patient, but some common pain medications such as amitriptyline, gabapentin and pregabalin have been shown to be effective in studies of adults and children. Susie East, CNN, "Migraines to cluster headaches: The most painful headaches you could ever have," 3 Oct. 2017

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'amitriptyline.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

First Known Use of amitriptyline

1961, in the meaning defined above

History and Etymology for amitriptyline

ami(no) + trypt(ophan) + -yl + -ine entry 2

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The first known use of amitriptyline was in 1961

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Cite this Entry

“Amitriptyline.” Dictionary, Merriam-Webster, Accessed 8 Mar. 2021.

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am·​i·​trip·​ty·​line | \ ˌam-ə-ˈtrip-tə-ˌlēn How to pronounce amitriptyline (audio) \

Medical Definition of amitriptyline

: a tricyclic antidepressant drug that is administered in the form of its hydrochloride C20H23N·HCl to prevent migraines and to treat neuropathic pain, bulimia, and depression

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