am·​i·​trip·​ty·​line | \ ˌa-mə-ˈtrip-tə-ˌlēn How to pronounce amitriptyline (audio) \

Definition of amitriptyline

: a tricyclic aromatic antidepressant drug used in the form of its hydrochloride C20H23N·HCl to prevent migraines and to treat neuropathic pain, bulimia, and depression

Examples of amitriptyline in a Sentence

Recent Examples on the Web People with more severe disease, or who don’t respond to treatment, should consider daily treatment to prevent attacks, such as amitriptyline, which is also used to prevent migraines. Dr. Keith Roach, oregonlive, 24 Mar. 2022 Some common preventative medications include: Tricyclic antidepressants: Specifically amitriptyline has been shown to reduce migraine by keeping serotonin levels steady in the brain. Abigail Libers, SELF, 9 Mar. 2022 In addition to the hyoscyamine, other medications used include: atropine eyedrops under the tongue; the antidepressant amitriptyline; and glycopyrrolate. Dr. Keith Roach, oregonlive, 3 Dec. 2021 Any idea whether it could be reversed, perhaps by stopping the amitriptyline? Dr. Keith Roach, oregonlive, 28 June 2021 Eventually, Mutchler found a doctor to evaluate her son and write the prescriptions for phenobarbital and amitriptyline. Time, 29 Mar. 2021 Antidepressants – Drugs like amitriptyline may be prescribed to shingles patients to alleviate postherpetic neuralgia., 1 May 2017 There's no specific treatment, and results vary from patient to patient, but some common pain medications such as amitriptyline, gabapentin and pregabalin have been shown to be effective in studies of adults and children. Susie East, CNN, 3 Oct. 2017 See More

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'amitriptyline.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

First Known Use of amitriptyline

1961, in the meaning defined above

History and Etymology for amitriptyline

ami(no) + trypt(ophan) + -yl + -ine entry 2

Learn More About amitriptyline

Time Traveler for amitriptyline

Time Traveler

The first known use of amitriptyline was in 1961

See more words from the same year

Dictionary Entries Near amitriptyline




See More Nearby Entries 

Statistics for amitriptyline

Last Updated

11 May 2022

Cite this Entry

“Amitriptyline.” Dictionary, Merriam-Webster, Accessed 18 May. 2022.

Style: MLA
MLACheck Mark Icon ChicagoCheck Mark Icon APACheck Mark Icon Merriam-WebsterCheck Mark Icon

More Definitions for amitriptyline


am·​i·​trip·​ty·​line | \ ˌam-ə-ˈtrip-tə-ˌlēn How to pronounce amitriptyline (audio) \

Medical Definition of amitriptyline

: a tricyclic antidepressant drug that is administered in the form of its hydrochloride C20H23N·HCl to prevent migraines and to treat neuropathic pain, bulimia, and depression

More from Merriam-Webster on amitriptyline Encyclopedia article about amitriptyline


Test Your Vocabulary

Eponyms: Words Named After People

How Strong Is Your Vocabulary?

Test your vocabulary with our 10-question quiz!

Universal Daily Crossword

A daily challenge for crossword fanatics.

Love words? Need even more definitions?

Subscribe to America's largest dictionary and get thousands more definitions and advanced search—ad free!