am·​i·​trip·​ty·​line ˌa-mə-ˈtrip-tə-ˌlēn How to pronounce amitriptyline (audio)
: a tricyclic aromatic antidepressant drug used in the form of its hydrochloride C20H23N·HCl to prevent migraines and to treat neuropathic pain, bulimia, and depression

Examples of amitriptyline in a Sentence

Recent Examples on the Web Medicines that are more specific for nerve pain, such as gabapentin or amitriptyline, are usually more effective than opiate-type medications in the long-term. Dr. Keith Roach, oregonlive, 18 Sep. 2023 The amitriptyline dosage for anxiety may also be modified in light of amitriptyline drug interactions. Verywell Health, 14 Feb. 2023 However, the authors found most of the studies on amitriptyline’s effectiveness were small and the evidence was not reliable. Katie Hunt, CNN, 9 May 2023 The English folk artist’s last official album – the only one released in North America during his lifetime, issued two years before his death of an amitriptyline overdose at age 26 – features only his hushed voice, an acoustic guitar, and a single piano line overdubbed onto the opening title track. Spin Staff, SPIN, 22 Apr. 2022 Others are for mood disorders, including Zoloft, amitriptyline, Remeron (mirtazapine), and Prozac (fluoxetine), all used to treat depression and anxiety. Jessica Bartlett,, 3 Feb. 2023 Examples of antidepressants that are used to treat chronic pain include Elavil (amitriptyline), Pamelor (nortriptyline), Cymbalta (duloxetine), and Effexor (venlafaxine). Carrie Madormo, Rn, Health, 23 Jan. 2023 Nowadays amitriptyline is rarely used for depression, because newer, less toxic alternatives are available. Neuroskeptic, Discover Magazine, 31 Dec. 2011 Other options include pregabalin and amitriptyline, while nonmedication options include sensory retraining therapy and massage. Dr. Keith Roach, oregonlive, 5 Oct. 2022 See More

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Word History

First Known Use

1961, in the meaning defined above

Time Traveler
The first known use of amitriptyline was in 1961

Dictionary Entries Near amitriptyline

Cite this Entry

“Amitriptyline.” Dictionary, Merriam-Webster, Accessed 1 Mar. 2024.

Medical Definition


am·​i·​trip·​ty·​line ˌam-ə-ˈtrip-tə-ˌlēn How to pronounce amitriptyline (audio)
: a tricyclic antidepressant drug that is administered in the form of its hydrochloride C20H23N·HCl to prevent migraines and to treat neuropathic pain, bulimia, and depression

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