aman·​ta·​dine ə-ˈman-tə-ˌdēn How to pronounce amantadine (audio)
: a drug used especially as the hydrochloride C10H17N·HCl to prevent infection (as by an influenza virus) by interfering with virus penetration into host cells

Examples of amantadine in a Sentence

Recent Examples on the Web Because of his extensive contacts after a lifetime of advocacy, Waldrep recommended a drug called amantadine, which previously had been used for the flu and had been granted orphan drug status by the FDA to treat Parkinson’s patients only a few months earlier. Dallas News, 29 Sep. 2022 The antiviral drug amantadine, for instance, was originally developed for influenza, but was repurposed as a Parkinson's therapy. Annette Bakker, Fortune, 5 July 2021 His main approach has been to target the mutation in the M2 channel that created resistance to amantadine and rimantadine. Neil Savage, Scientific American, 18 Sep. 2019 What’s more, the flu virus has developed resistance to oseltamivir and to an older drug, amantadine. Kai Kupferschmidt, Science | AAAS, 23 Oct. 2019 Nearly all the viruses in circulation around the globe had a mutation that rendered amantadine and rimantadine—the two adamantanes used to treat flu, which work by blocking a particular step in viral replication—completely useless. Neil Savage, Scientific American, 18 Sep. 2019 There are only two other classes of flu drugs, neuraminidase inhibitors (drugs like Tamiflu, Relenza, Rapivab) and the adamantane drugs (amantadine and rimantadine). Helen Branswell, STAT, 27 June 2018 Influenza viruses developed resistance long ago to the first two antiviral flu drugs, amantadine and rimantadine. NBC News, 26 June 2018 See More

These examples are programmatically compiled from various online sources to illustrate current usage of the word 'amantadine.' Any opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback about these examples.

Word History


International Scientific Vocabulary amantad- (alteration of adamantane, C10H16) + amine

First Known Use

1964, in the meaning defined above

Time Traveler
The first known use of amantadine was in 1964

Dictionary Entries Near amantadine

Cite this Entry

“Amantadine.” Dictionary, Merriam-Webster, Accessed 3 Mar. 2024.

Medical Definition


aman·​ta·​dine ə-ˈmant-ə-ˌdēn How to pronounce amantadine (audio)
: a drug administered orally especially in the form of its hydrochloride C10H17N·HCl to prevent infection (as by the virus causing influenza A) by interfering with virus penetration into host cells and in the treatment of Parkinson's disease see symmetrel

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