aman·​ta·​dine | \ ə-ˈman-tə-ˌdēn How to pronounce amantadine (audio) \

Definition of amantadine

: a drug used especially as the hydrochloride C10H17N·HCl to prevent infection (as by an influenza virus) by interfering with virus penetration into host cells

Examples of amantadine in a Sentence

Recent Examples on the Web His main approach has been to target the mutation in the M2 channel that created resistance to amantadine and rimantadine. Neil Savage, Scientific American, "The push for better flu therapies," 18 Sep. 2019 What’s more, the flu virus has developed resistance to oseltamivir and to an older drug, amantadine. Kai Kupferschmidt, Science | AAAS, "New drug forces flu virus into ‘error catastrophe,’ overwhelming it with mutations," 23 Oct. 2019 Nearly all the viruses in circulation around the globe had a mutation that rendered amantadine and rimantadine—the two adamantanes used to treat flu, which work by blocking a particular step in viral replication—completely useless. Neil Savage, Scientific American, "The push for better flu therapies," 18 Sep. 2019 There are only two other classes of flu drugs, neuraminidase inhibitors (drugs like Tamiflu, Relenza, Rapivab) and the adamantane drugs (amantadine and rimantadine). Helen Branswell, STAT, "A flu drug — shown to reduce the duration of symptoms — could upend treatment in U.S.," 27 June 2018 Influenza viruses developed resistance long ago to the first two antiviral flu drugs, amantadine and rimantadine. NBC News, "New, fast-acting flu drug gets priority FDA review," 26 June 2018

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'amantadine.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

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First Known Use of amantadine

1964, in the meaning defined above

History and Etymology for amantadine

International Scientific Vocabulary amantad- (alteration of adamantane, C10H16) + amine

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Time Traveler for amantadine

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The first known use of amantadine was in 1964

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Cite this Entry

“Amantadine.” Dictionary, Merriam-Webster, Accessed 18 May. 2021.

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More Definitions for amantadine


aman·​ta·​dine | \ ə-ˈmant-ə-ˌdēn How to pronounce amantadine (audio) \

Medical Definition of amantadine

: a drug administered orally especially in the form of its hydrochloride C10H17N·HCl to prevent infection (as by the virus causing influenza A) by interfering with virus penetration into host cells and in the treatment of Parkinson's disease — see symmetrel

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