allogeneic

adjective

al·​lo·​ge·​ne·​ic ˌa-lō-jə-ˈnē-ik How to pronounce allogeneic (audio)
variants or less commonly allogenic
1
usually allogeneic : involving, derived from, or being individuals of the same species that are sufficiently unlike genetically to interact antigenically
allogeneic stem cells
allogeneic marrow transplantation
compare syngeneic
2
allogenic : caused by the action or influence of abiotic environmental factors
allogenic (disturbance) processes, such as flooding and sediment deposition patterns, in addition to wind events.Brian Lockhart et al.

Examples of allogeneic in a Sentence

Recent Examples on the Web The second risk for donor-derived, allogeneic therapies is tissue rejection; this occurs when the body treats the new cells as a foreign threat. William A. Haseltine, Forbes, 14 Feb. 2024 This is an adverse reaction to an allogeneic transplant. Sarah Fielding, Health, 9 Mar. 2023 The second type, allogeneic hematopoietic stem cell transplantation (HSCT), is more common and involves finding a donation from another person. Emilie Le Beau Lucchesi, Discover Magazine, 17 Feb. 2023 The advent of allogeneic approaches to CAR T therapy is on the rise as new techniques are developed to further translate the potential of CAR T in the clinic. Demaris Mills, Forbes, 10 Aug. 2022 Though more research is needed, this serves as an early proof of concept outlining some of the potential advantages of an allogeneic approach over autologous CAR T-cells. Demaris Mills, Forbes, 10 Aug. 2022 Autologous and allogeneic therapy are the future of drug development. John Cumbers, Forbes, 25 Jan. 2022 The rest get allogeneic transplants, where donors can include siblings or unrelated donors determined to be a match. Ron Winslow, WSJ, 28 May 2018 The company is taking over Pfizer Inc.’s collaboration and license agreement with Cellectis to develop a series of allogeneic CAR-T therapies, including UCART19, a blood cancer drug in Phase I clinical trials. Brian Gormley, WSJ, 3 Apr. 2018

These examples are programmatically compiled from various online sources to illustrate current usage of the word 'allogeneic.' Any opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback about these examples.

Word History

Etymology

alteration of allogenic, from allo- + -genic

Note: The word allogenic as a term in genetics was introduced by the British immunologist Peter A. Gorer (1907-61) in the article "Transplantese," Annals of the New York Academy of Science, vol. 87, no. 1 (May, 1960), pp. 604-606. In a subsequent article (P. A. Gorer, et al., "Proposed revisions of 'Transplantese'," Nature, vol. 189, no. 4769 (March 25, 1961), pp. 1024-25), the suggestion is made that allogenic be changed to allogeneic to avoid confusion with allergenic. The later article also introduces syngeneic as a synonym for earlier isogenic.

First Known Use

1929, in the meaning defined at sense 2

Time Traveler
The first known use of allogeneic was in 1929

Dictionary Entries Near allogeneic

Cite this Entry

“Allogeneic.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/allogeneic. Accessed 25 May. 2024.

Medical Definition

allogeneic

adjective
al·​lo·​ge·​ne·​ic ˌal-ō-jə-ˈnē-ik How to pronounce allogeneic (audio)
variants also allogenic
: involving, derived from, or being individuals of the same species that are sufficiently unlike genetically to interact antigenically
allogeneic skin grafts
compare syngeneic, xenogeneic
Love words? Need even more definitions?

Subscribe to America's largest dictionary and get thousands more definitions and advanced search—ad free!