adrenoleukodystrophy

noun

ad·re·no·leu·ko·dys·tro·phy ə-ˈdrē-nō-ˌlü-kō-ˈdi-strə-fē

: a rare demyelinating disease of the central nervous system that is inherited as a sex-linked recessive trait chiefly affecting males in childhood and that is characterized by progressive blindness, deafness, tonic spasms, and mental deterioration

—abbreviation ALD

Example Sentences

Recent Examples on the Web Working under the deadline of a fatal illness, the Odones created a novel treatment for adrenoleukodystrophy, which disrupts fat metabolism, primarily in boys. —

Delthia Ricks, Discover Magazine, 5 Oct. 2011 The challenge is that the two diseases Bluebird’s therapies treat—beta thalassemia and cerebral adrenoleukodystrophy, or CALD—afflict tiny portions of the population, therefore limiting their economic potential. —

David Wainer, WSJ, 3 Oct. 2022 Skysona is designed to restore a crucial gene that is broken in children with a condition called cerebral adrenoleukodystrophy. —

Ryan Cross, BostonGlobe.com, 17 Sep. 2022 Bluebird’s first treatment, eli-cel, helped children with a lethal neurodegenerative disease called cerebral adrenoleukodystrophy live longer by supplying them with a gene that’s crucial for the proper functioning of brain cells. —

Globe Staff, BostonGlobe.com, 19 June 2022 The medicine, eli-cel, is a one-time treatment for cerebral adrenoleukodystrophy, a genetic neurological disorder that affects young boys. —

Ed Silverman, STAT, 13 June 2022 On Thursday, Bluebird presented data indicating that 92 percent of children with cerebral adrenoleukodystrophy were still alive two years after eli-cel treatment compared to 57 percent of those without treatment. —

Ryan Cross, BostonGlobe.com, 10 June 2022 For example, Bluebird bio saw a big setback as some safety issues emerged in an ongoing study of a drug to treat cerebral adrenoleukodystrophy back in August. —

Trefis Team, Forbes, 23 Dec. 2021 At the same time, its stock dropped 25.9% after disclosing new safety issues with an experimental gene therapy under development to treat cerebral adrenoleukodystrophy, a rare genetic condition. —

Ed Silverman, STAT, 12 Aug. 2021 See More

These examples are programmatically compiled from various online sources to illustrate current usage of the word 'adrenoleukodystrophy.' Any opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback about these examples.

Word History

Etymology

adreno- + leukodystrophy

First Known Use

1973, in the meaning defined above

Time Traveler

The first known use of adrenoleukodystrophy was in 1973

See more words from the same year

Dictionary Entries Near adrenoleukodystrophy

adrenocorticotropin

adrenoleukodystrophy

adrenoxine

See More Nearby Entries

Cite this Entry

Style

“Adrenoleukodystrophy.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/adrenoleukodystrophy. Accessed 2 Apr. 2023.

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Medical Definition

adrenoleukodystrophy

noun

adre·no·leu·ko·dys·tro·phy

variants or chiefly British adrenoleucodystrophy

-ˌlü-kō-ˈdis-trə-fē

plural adrenoleukodystrophies

: a rare demyelinating disease of the central nervous system that is inherited as an X-linked recessive trait chiefly affecting males in childhood and that is characterized by progressive blindness, deafness, tonic spasms, and mental deterioration

—abbreviation ALD

called also encephalitis periaxialis diffusa, Schilder's disease, Schilder's encephalitis