side effect

noun

: a secondary and usually adverse effect (as of a drug)
toxic side effects

called also side reaction

Examples of side effect in a Sentence

Nausea and diarrhea are the side effects of the drug. the harmful side effects of using chemicals to kill insects The merger created positive side effects for both companies.
Recent Examples on the Web
Examples are automatically compiled from online sources to show current usage. Read More Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback.
Researchers have revealed a surprising new side effect linked to GLP-1 agonists, such as Ozempic, Wegovy, Mounjaro and Zepbound. Melissa Rudy, FOXNews.com, 10 Oct. 2025 There is no information about side effects. Heather Jones, Verywell Health, 10 Oct. 2025 Of both ethical and professional reasons, that does come with a dose of side effects. Lexy Perez, HollywoodReporter, 10 Oct. 2025 Their runaway success of the appetite-supppressing drugs has drastically altered conversations around weight-loss and health, challenging expectations and sparking controversy over their proper use and side effects. Merrill Fabry, Time, 9 Oct. 2025 See All Example Sentences for side effect

Word History

First Known Use

1814, in the meaning defined above

Time Traveler
The first known use of side effect was in 1814

Browse Nearby Words

Cite this Entry

“Side effect.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/side%20effect. Accessed 12 Oct. 2025.

Kids Definition

side effect

noun
: an often harmful and unwanted effect (as of a drug) that occurs along with the basic desired effect
the environmental side effects of using chemicals to kill pests

Medical Definition

side effect

noun
: a secondary and usually adverse effect (as of a drug)
toxic side effects
a side effect of drowsiness caused by antihistamines

called also side reaction

Last Updated: - Updated example sentences
Love words? Need even more definitions?

Subscribe to America's largest dictionary and get thousands more definitions and advanced search—ad free!