Definition of Santa Cruz
1 island in the Pacific off southwestern California in the northwestern Channel Islands
2 city in western California south of San Jose on Monterey Bay population 59,946
3 — see saint croix
4 river 250 miles (402 kilometers) long in southern Argentina flowing east into the Atlantic Ocean
5 city in eastern Bolivia population 1,448,000
Seen and Heard
What made you want to look up Santa Cruz? Please tell us where you read or heard it (including the quote, if possible).