GLP

abbreviation or noun

ˌjē-(ˌ)el-ˈpē 

plural GLPs

: either of two intestinal hormones secreted together when nutrients (such as carbohydrates and lipids) are present in the small intestine:

a

or GLP-1

-ˈwən 

: one that stimulates insulin secretion, inhibits glucagon secretion, slows the movement of stomach contents into the small intestine, and promotes feelings of satiety : glucagon-like peptide-1

After a meal, the body releases GLP-1 to signal satiety and stimulate insulin-secreting beta cells in the pancreas.

—Nathan Seppa

b

or GLP-2

-ˈtü 

: one that stimulates cell proliferation in the intestinal mucosa and has little effect on insulin secretion : glucagon-like peptide-2

Word History

First Known Use

1983, in the meaning defined above

Medical Definition

GLP

abbreviation

glucagon-like peptide

—often used with the number 1 or 2 to indicate the specific peptide

GLP-1