enkephalin

noun

en·​keph·​a·​lin in-ˈke-fə-lən How to pronounce enkephalin (audio)
-(ˌ)lin
en-
: either of two pentapeptides with opiate and analgesic activity that occur naturally especially in the brain and have a marked affinity for opiate receptors compare endorphin

Examples of enkephalin in a Sentence

Recent Examples on the Web
Examples are automatically compiled from online sources to show current usage. Read More Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback.
One potential approach is targeting T-regs directly to increase the production of the painkiller enkephalin, which ultimately would benefit both women and men. Jenny Lehmann, Discover Magazine, 7 Apr. 2025 The researchers have also begun looking at the engineering T-regs to produce enkephalin in both women and men, offering a new path toward treating chronic pain. Michael Franco, New Atlas, 4 Apr. 2025 During that time, your body tends to produce less endorphins and enkephalins, which are natural pain-killers, than at any other time of day, according to the National Headache Foundation. Korin Miller, SELF, 24 Aug. 2017

Word History

Etymology

enkephal- (alteration of encephal-) + -in

First Known Use

1975, in the meaning defined above

Time Traveler
The first known use of enkephalin was in 1975

Browse Nearby Words

Cite this Entry

“Enkephalin.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/enkephalin. Accessed 5 Jul. 2026.

Medical Definition

enkephalin

noun
en·​keph·​a·​lin in-ˈkef-ə-lən, -(ˌ)lin How to pronounce enkephalin (audio)
: either of two pentapeptide endorphins:

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