Down syndrome

noun

variants or Down's syndrome
: a congenital condition characterized especially by developmental delays, usually mild to moderate impairment in cognitive functioning, short stature, upward slanting eyes, a flattened nasal bridge, broad hands with short fingers, decreased muscle tone, and by trisomy of the human chromosome numbered 21

called also trisomy 21

Examples of Down syndrome in a Sentence

Recent Examples on the Web Kane, who has Down syndrome, has done most jobs at the restaurant and, since 2009, trained many of her co-workers. Mary Divine, Twin Cities, 17 May 2024 Other genetic cases are linked to Down syndrome—about half of people with Down syndrome in their 60s have Alzheimer’s. Will Sullivan, Smithsonian Magazine, 7 May 2024 This is simply a thorough ultrasound (it's often done in combination with the NIPT blood test) that screens for different markers of Down syndrome, trisomy 13, trisomy 18, and other chromosomal abnormalities. Christin Perry, Parents, 6 May 2024 Erskine’s fourth child, Jimmy, was born with Down syndrome. Houston Mitchell, Los Angeles Times, 19 Apr. 2024 Gigi’s Playhouse is a 501c3 nonprofit created to support people diagnosed with Down syndrome and their families. Meghan Overdeep, Southern Living, 18 Apr. 2024 His support of the Special Olympics and related causes, inspired by his son Jimmy, who led a life beyond all expectations when he was born with Down syndrome, cemented his legacy. CBS News, 16 Apr. 2024 The incidence of Down syndrome rose in early Iron Age Spain. Nick Bowlin, Harper's Magazine, 30 Mar. 2024 According to the complaint, the family was sitting at a nearby table when George approached them and started mocking the couple's daughter, who was described as having Down syndrome and was wheelchair bound. Stepheny Price, Fox News, 5 Apr. 2024

These examples are programmatically compiled from various online sources to illustrate current usage of the word 'Down syndrome.' Any opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback about these examples.

Word History

Etymology

J. L. H. Down †1896 English physician

First Known Use

1961, in the meaning defined above

Time Traveler
The first known use of Down syndrome was in 1961

Dictionary Entries Near Down syndrome

Cite this Entry

“Down syndrome.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/Down%20syndrome. Accessed 26 May. 2024.

Kids Definition

Down syndrome

noun
ˈdau̇n-
variants or Down's syndrome
ˈdau̇n(z)-
: a genetic condition characterized especially by developmental delays, by distinctive physical traits (as short stature and upward slanting eyes), and by the presence of three chromosomes numbered 21 in human beings
Etymology

named for J.L.H. Down, 1828–1896, English doctor

Medical Definition

Down syndrome

noun
variants or Down's syndrome
: a congenital condition characterized especially by developmental delays, usually mild to moderate impairment in cognitive functioning, short stature, relatively small head, upward slanting eyes usually with epicanthal folds, flattened nasal bridge, broad hands with short fingers, decreased muscle tone, and by trisomy of the human chromosome numbered 21

called also Down, Down's, trisomy 21

More from Merriam-Webster on Down syndrome

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