cortisol

noun

cor·​ti·​sol ˈkȯr-tə-ˌsȯl How to pronounce cortisol (audio)
-ˌzȯl
-ˌsōl
-ˌzōl
: a glucocorticoid C21H30O5 produced by the adrenal cortex upon stimulation by ACTH that mediates various metabolic processes (such as gluconeogenesis), has anti-inflammatory and immunosuppressive properties, and whose levels in the blood may become elevated in response to physical or psychological stress

called also hydrocortisone

Examples of cortisol in a Sentence

Recent Examples on the Web
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These tests, done through extensive bloodwork, measure everything from testosterone and environmental toxins to cortisol and insulin—almost 180 biomarkers get checked. Justin Fenner, Robb Report, 14 May 2026 The authors suggest that because exercise boosts feel-good hormones, such as dopamine, and reduces the stress hormone cortisol, smokers who work out feel less inclined to use nicotine as a brain reward. Teresa Mull, FOXNews.com, 9 May 2026 Even dim light during sleep can raise next-day cortisol and disrupt sleep quality. Allison Palmer, Charlotte Observer, 9 May 2026 My cortisol would be raised to levels previously unexplored by human beings. Sam Stone, Bon Appetit Magazine, 8 May 2026 See All Example Sentences for cortisol

Word History

Etymology

cortisone + -ol entry 1

First Known Use

1951, in the meaning defined above

Time Traveler
The first known use of cortisol was in 1951

Browse Nearby Words

Cite this Entry

“Cortisol.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/cortisol. Accessed 17 May. 2026.

Medical Definition

cortisol

noun
: a glucocorticoid C21H30O5 produced by the adrenal cortex upon stimulation by ACTH that mediates various metabolic processes (as gluconeogenesis), has anti-inflammatory and immunosuppressive properties, and whose levels in the blood may become elevated in response to physical or psychological stress

called also hydrocortisone

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