: a glucocorticoid C21H28O5 that is produced naturally in small amounts by the adrenal cortex and is administered in the form of its synthetic acetate C23H30O6 especially as replacement therapy for deficient adrenocortical secretion and as an anti-inflammatory agent (as for rheumatoid arthritis)—compare 11-dehydrocorticosterone
Steroidhormone produced by the adrenal cortex (seeadrenal gland). It participates in the regulation of the conversion of proteins to carbohydrates, and to some extent it regulates salt metabolism. Introduced medically in 1948 for its anti-inflammatory effect to treat arthritis, it has been largely replaced by related compounds that do not produce its undesired side effects, which include edema, increased stomach acidity, and imbalances in sodium, potassium, and nitrogen metabolism. See alsoCushing syndrome.