To run interference means to provide assistance by or as if by clearing a path through obstructions. In football, it describes the effort of the offensive players to block the defensive players from reaching the player in possession of the ball.
On that play, the Eagles used their biggest receiver, 6-foot-4 Mack Hollins, to run interference on Vikings safety Harrison Smith, who had been assigned man-to-man coverage on Ertz.
— Andrew Krammer, The Star Tribune (Minneapolis), 1 Sept. 2018
Idol plays himself in the film as a first-class passenger on a flight headed to Las Vegas. He gives Sandler’s character sage advice on how to win back his love and even helps run interference when Sandler makes his move.
— John Clyde, KSL.com, 25 Aug. 2018