tyrosine kinase

noun

Medical Definition of tyrosine kinase 

: any of a group of enzymes of protein kinase that catalyze the transfer of a phosphate group from ATP to a tyrosine residue in a protein’s side chain

Note: Some tyrosine kinases are enzymes that act as cell membrane receptors by binding to extracellular ligands and activating intracellular signaling pathways, while others are enzymes that act in those pathways by regulating intracellular processes.

Other targeted agents that have been evaluated in phase 2 clinical trials for the treatment of hepatocellular carcinoma include tyrosine kinase inhibitors of the epidermal growth factor receptor …— Josep M. Llovet et al., The New England Journal of Medicine, 24 July 2008

Learn More about tyrosine kinase

Share tyrosine kinase

Comments on tyrosine kinase

What made you want to look up tyrosine kinase? Please tell us where you read or heard it (including the quote, if possible).

WORD OF THE DAY

to clear from alleged fault or guilt

Get Word of the Day daily email!

Test Your Vocabulary

Difficult Vocab Quiz

  • the-education-of-achilles-eugne-delacroix
  • Which is a synonym of discomfit?
Spell It

Can you spell these 10 commonly misspelled words?

TAKE THE QUIZ
SCRABBLE® Sprint

Test Your Knowledge - and learn some interesting things along the way.

TAKE THE QUIZ

Love words? Need even more definitions?

Subscribe to America's largest dictionary and get thousands more definitions and advanced search—ad free!