taxane

noun
tax·​ane | \ ˈtak-ˌsān How to pronounce taxane (audio) \

Medical Definition of taxane

: any of various tricyclic compounds (as docetaxel and paclitaxel) with anticancer activity that are obtained from yew trees (genus Taxus) or are made synthetically

Note: Taxanes act by binding tubulin, thereby promoting microtubule formation and arresting cell division.

The taxanes are an important new class of anticancer agents that exert their cytotoxic effects through a unique mechanism.— Eric K. Rowinsky and Ross C. Donehower, The New England Journal of Medicine, 13 Apr. 1995 Some cancers, though, are armored against taxanes: Their cell membranes carry a multiple-drug-resistance pump that identifies taxanes as a threat and pumps them out before they can infiltrate the cell.— Jonathan Fahey, Forbes, 28 May 2001

Learn More about taxane

Cite this Entry

“Taxane.” Merriam-Webster.com Medical Dictionary, Merriam-Webster, https://www.merriam-webster.com/medical/taxane. Accessed 1 Dec. 2020.

Comments on taxane

What made you want to look up taxane? Please tell us where you read or heard it (including the quote, if possible).

WORD OF THE DAY

Test Your Vocabulary

Musical Words Quiz

  • gramophone
  • Which word describes a musical performance marked by the absence of instrumental accompaniment?
Spell It

Can you spell these 10 commonly misspelled words?

TAKE THE QUIZ
Bee Cubed

Test Your Knowledge - and learn some interesting things along the way.

TAKE THE QUIZ
Love words? Need even more definitions?

Subscribe to America's largest dictionary and get thousands more definitions and advanced search—ad free!