tachyphylaxis

noun
tachy·​phy·​lax·​is | \ˌtak-i-fi-ˈlak-səs \
plural tachyphylaxes\ -​ˌsēz \

Medical Definition of tachyphylaxis 

: diminished response to later increments in a sequence of applications of a physiologically active substance (as the diminished pressor response that follows repeated injections of renin)

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