spectrin

noun

spec·trin | \ ˈspek-trən

Medical Definition of spectrin

: a large cytoskeletal protein that is found on the inner cell membrane of red blood cells and that functions especially in maintaining cell shape The erythrocyte cytoskeleton, which consists primarily of a meshwork of spectrin and actin, controls cell shape and the disposition of protein within the membrane.— Robert Siman et al., Nature, 17 Jan. 1985 A number of genetic diseases (hemolytic anemias) characterized by fragile, abnormally shaped erythrocytes have been traced to mutations in ankyrin or spectrin. — Gerald Karp, Cell and Molecular Biology: Concepts and Experiments, 6th edition, 2010