Medical Dictionary

spectrin

noun spec·trin \ ˈspek-trən \

medical Definition of spectrin

:a large cytoskeletal protein that is found on the inner cell membrane of red blood cells and that functions especially in maintaining cell shape
  • The erythrocyte cytoskeleton, which consists primarily of a meshwork of spectrin and actin, controls cell shape and the disposition of protein within the membrane.
  • —Robert Siman et al.Nature17 Jan. 1985
  • A number of genetic diseases (hemolytic anemias) characterized by fragile, abnormally shaped erythrocytes have been traced to mutations in ankyrin or spectrin.
  • —Gerald Karp, Cell and Molecular Biology: Concepts and Experiments, 6th edition2010

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