medical Definition of serpin
- The identification of an intracellular serpin (protease inhibitor) that prevents necrosis caused by multiple noxious stimuli indicates that necrosis can be regulated, programmed, and driven by a peptidase stress-response pathway.
- —Richard S. Hotchkiss, M.D. et al., The New England Journal of Medicine, 15 Oct. 2009
- Apparently evolution has completely adapted the serpin structure for its new role in these proteins as a transport agent, as there is no evidence of any retained protease inhibitory activity.
- —Daniel F. Voytas, et al., letter in Nature, 17 Nov. 1988