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ro·fe·cox·ib | \ ˌrō-fe-ˈkäk-sib 
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\Medical Definition of rofecoxib
: a COX-2 inhibitor C17H14O4S used to relieve the signs and symptoms of osteoarthritis and rheumatoid arthritis, to manage acute pain in adults, and to treat primary dysmenorrhea but withdrawn from sale by the manufacturer because of its link to cardiovascular events (as heart attack and stroke) — see vioxx
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