medical Definition of peau d'orange
: thickened, dimpled skin that resembles the rind of an orange and is often associated with some forms of breast cancer
- There was a mass, 6 to 7 cm in diameter, in the upper outer quadrant of the right breast … and the overlying skin had peau d'orange changes, without erythema.
- —José Baselga et al., The New England Journal of Medicine, 24 May 2012
