multiple system atrophy
Medical Definition of multiple system atrophy
: any of several progressive neurodegenerative diseases that are of unknown cause, have an onset usually during middle age and are characterized by a combination of symptoms (as orthostatic hypotension, urinary incontinence, rigidity, and loss of balance) indicative of autonomic dysfunction, parkinsonism, and cerebellar ataxia—abbreviation MSA; see shy-drager syndrome
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