mediastinum

noun

me·​di·​as·​ti·​num ˌmē-dē-ə-ˈstī-nəm How to pronounce mediastinum (audio)
plural mediastina ˌmē-dē-ə-ˈstī-nə How to pronounce mediastinum (audio)
: the space in the chest between the pleural sacs of the lungs that contains all the tissues and organs of the chest except the lungs and pleurae
also : this space with its contents
mediastinal adjective

Examples of mediastinum in a Sentence

Recent Examples on the Web
Examples are automatically compiled from online sources to show current usage. Read More Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback.
According to the Dana-Farber Cancer Institute, this type of cancer usually starts in the upper chest area called the mediastinum. Jordan Greene, Peoplemag, 23 Apr. 2024 The swollen lymph nodes in the mediastinum were also associated with a higher risk of admission to an intensive care unit (ICU). Korin Miller, Health, 25 Sep. 2023 Based on the CT scan results, Matt’s mediastinum only seemed to have air in it and did not look to be infected just yet. Douglas G. Adler, Discover Magazine, 14 Dec. 2021 Limited-stage disease is used to describe lung cancer that’s only found within one lung, and may be found in the mediastinum between the lungs. Amanda MacMillan, Health.com, 23 July 2019

Word History

Etymology

New Latin, from Medieval Latin, neuter of mediastinus medial, from Latin medius

First Known Use

15th century, in the meaning defined above

Time Traveler
The first known use of mediastinum was in the 15th century

Browse Nearby Words

Cite this Entry

“Mediastinum.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/mediastinum. Accessed 10 Sep. 2025.

Medical Definition

mediastinum

noun
me·​di·​as·​ti·​num ˌmēd-ē-ə-ˈstī-nəm How to pronounce mediastinum (audio)
plural mediastina -nə How to pronounce mediastinum (audio)
1
: the space in the chest between the pleural sacs of the lungs that contains all the viscera of the chest except the lungs and pleurae
also : this space with its contents
2

More from Merriam-Webster on mediastinum

Love words? Need even more definitions?

Subscribe to America's largest dictionary and get thousands more definitions and advanced search—ad free!