: any of various simple water-soluble proteins that are rich in the basic amino acids lysine and arginine and are complexed with DNA in the nucleosomes of eukaryotic chromatin
Examples of histone in a Sentence
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Work in animal models has also shown that exercise changes gene expression by altering both histones and the molecular tags directly attached to DNA.
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Karla Kaun, Discover Magazine, 26 Jan. 2024
In their new study, scientists at McGill University in Canada, used genetic engineering to alter the activity of one of the histone proteins that controls epigenetic processes – KDM1A histone lysine 4 demethylase – during the production of sperm in mice.
—Paul Haggarty, Discover Magazine, 13 Oct. 2015
The histone in question is one known as PRDM2.
—Joshua Hawkins, BGR, 11 Oct. 2022
It is controlled by methylation changes to CpG islands on promoter regions, the remodeling of chromatin using histone modifications, and the alteration of gene expression through non-coding RNA expression.
—Salvatore Viscomi, Forbes, 22 Mar. 2023
Additionally, a variety of epigenetic changes (mediated, for example, by DNA methylation, histone modification and transfer of non-coding RNAs) also appear to increase with advancing maternal age (ref & ref).
—Grrlscientist, Forbes, 10 Oct. 2022
By binding to the H3 histone, serotonin and dopamine can regulate transcription of DNA into RNA and, as a consequence, the synthesis of specific proteins from them.
—Quanta Magazine, 27 Oct. 2020
In the nucleus, DNA is bound to proteins called histones to make a complex called chromatin, which in turn forms chromosomes.
—Bradley J. Fikes, sandiegouniontribune.com, 27 July 2017
Karla Kaun, Discover Magazine, 26 Jan. 2024
In their new study, scientists at McGill University in Canada, used genetic engineering to alter the activity of one of the histone proteins that controls epigenetic processes – KDM1A histone lysine 4 demethylase – during the production of sperm in mice.
—Paul Haggarty, Discover Magazine, 13 Oct. 2015
The histone in question is one known as PRDM2.
—Joshua Hawkins, BGR, 11 Oct. 2022
It is controlled by methylation changes to CpG islands on promoter regions, the remodeling of chromatin using histone modifications, and the alteration of gene expression through non-coding RNA expression.
—Salvatore Viscomi, Forbes, 22 Mar. 2023
Additionally, a variety of epigenetic changes (mediated, for example, by DNA methylation, histone modification and transfer of non-coding RNAs) also appear to increase with advancing maternal age (ref & ref).
—Grrlscientist, Forbes, 10 Oct. 2022
By binding to the H3 histone, serotonin and dopamine can regulate transcription of DNA into RNA and, as a consequence, the synthesis of specific proteins from them.
—Quanta Magazine, 27 Oct. 2020
In the nucleus, DNA is bound to proteins called histones to make a complex called chromatin, which in turn forms chromosomes.
—Bradley J. Fikes, sandiegouniontribune.com, 27 July 2017
These examples are programmatically compiled from various online sources to illustrate current usage of the word 'histone.' Any opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback about these examples.
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“Histone.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/histone. Accessed 20 Apr. 2024.
Copy CitationMedical Definition
histone
noun
his·tone
ˈhis-ˌtōn 
: any of various simple water-soluble proteins that are rich in the basic amino acids lysine and arginine and are complexed with DNA in the nucleosomes of eukaryotic chromatin
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