factor V Leiden

noun
factor V Lei·​den | \ -ˈlī-dᵊn How to pronounce factor V Leiden (audio) \

Medical Definition of factor V Leiden

1 : a point mutation producing an abnormal version of factor V that is resistant to inactivation and causes prolonged clotting of blood
2 also factor V Leiden thrombophilia : a genetic disorder caused by factor V Leiden that is marked by an increased risk of abnormal blood clot formation leading especially to deep vein thrombosis or pulmonary embolism

Note: Factor V Leiden is inherited as an autosomal dominant trait requiring that only one parent pass on a copy of the defective gene on a chromosome other than a sex chromosome. When both parents carry the defective gene, factor V Leiden is inherited as a recessive, more serious condition.

Learn More about factor V Leiden

Cite this Entry

“Factor V Leiden.” Merriam-Webster.com Medical Dictionary, Merriam-Webster, https://www.merriam-webster.com/medical/factor%20V%20Leiden. Accessed 22 Sep. 2020.

Comments on factor V Leiden

What made you want to look up factor V Leiden? Please tell us where you read or heard it (including the quote, if possible).

WORD OF THE DAY

Test Your Vocabulary

Homophone Quiz

  • three bears two of them look like theyre whispering to a third bear who looks chuffed to be the center of attention
  • In order to judge how people felt, the senator's office hired a firm to take a ______.
Spell It

Can you spell these 10 commonly misspelled words?

TAKE THE QUIZ
Bee Cubed

Test Your Knowledge - and learn some interesting things along the way.

TAKE THE QUIZ
Love words? Need even more definitions?

Subscribe to America's largest dictionary and get thousands more definitions and advanced search—ad free!