Medical Dictionary

factor V Leiden

noun factor V Lei·den \-ˈlī-dən\

Medical Definition of factor V Leiden

  1. 1:  a point mutation producing an abnormal version of factor V that is resistant to inactivation and causes prolonged clotting of blood

  2. 2 also factor V Leiden thrombophilia :  a genetic disorder caused by factor V Leiden that is marked by an increased risk of abnormal blood clot formation leading especially to deep vein thrombosis or pulmonary embolism Factor V Leiden is inherited as an autosomal dominant trait requiring that only one parent pass on a copy of the defective gene on a chromosome other than a sex chromosome. When both parents carry the defective gene, factor V Leiden is inherited as a recessive, more serious condition.

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