factor V Leiden

noun

factor V Lei·​den -ˈlī-dᵊn How to pronounce factor V Leiden (audio)
1
: a point mutation producing an abnormal version of factor V that is resistant to inactivation and causes prolonged clotting of blood
2
also factor V Leiden thrombophilia : a genetic disorder caused by factor V Leiden that is marked by an increased risk of abnormal blood clot formation leading especially to deep vein thrombosis or pulmonary embolism

Note: Factor V Leiden is inherited as an autosomal dominant trait requiring that only one parent pass on a copy of the defective gene on a chromosome other than a sex chromosome. When both parents carry the defective gene, factor V Leiden is inherited as a recessive, more serious condition.

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Cite this Entry

“Factor V Leiden.” Merriam-Webster.com Medical Dictionary, Merriam-Webster, https://www.merriam-webster.com/medical/factor%20V%20Leiden. Accessed 8 Feb. 2023.

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