endorphin

noun

en·​dor·​phin en-ˈdȯr-fən How to pronounce endorphin (audio)
: any of a group of endogenous peptides (such as enkephalin) found especially in the brain that bind chiefly to opiate receptors and produce some pharmacological effects (such as pain relief) like those of opiates
specifically : beta-endorphin

Did you know?

The word endorphin was coined, back when the substances were discovered in the 1970s, by joining pieces of endogenous and morphine, morphine being a narcotic that closely resembles the endorphins and relieves pain in a similar way. Studies suggest that the pain-relieving practice called acupuncture works by releasing endorphins. Endorphins also seem to play an important role in pregnancy. Though much remains to be learned about the endorphins, the general public seems ready to give them credit for any all-natural high.

Examples of endorphin in a Sentence

Recent Examples on the Web
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According to Bernadette Boden-Albala, MPH, DrPH, founding dean of the UC Irvine Joe C. Wen School of Population & Public Health, movement also increases blood flow to the brain, prompting the release of endorphins and other feel-good chemicals. Julia Ries Wexler, Health, 14 Aug. 2025 Having a regular exercise regime boosts blood flow, endorphins and energy, sharpening clarity, resilience and decision-making under pressure. Expert Panel®, Forbes.com, 12 Aug. 2025 The endorphins, the adrenaline — the joy of it — as well as the new challenges that stress the mind in a good way would be very mentally stimulating. Deborah Vankin, Los Angeles Times, 2 June 2025 The release of endorphins and the escape from everyday life, coupled with environmental stimulation, are all associated with gambling addiction. Tim Corlett, Forbes.com, 11 July 2025 See All Example Sentences for endorphin

Word History

Etymology

International Scientific Vocabulary endogenous + morphine

First Known Use

1976, in the meaning defined above

Time Traveler
The first known use of endorphin was in 1976

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Cite this Entry

“Endorphin.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/endorphin. Accessed 21 Aug. 2025.

Medical Definition

endorphin

noun
en·​dor·​phin en-ˈdȯr-fən How to pronounce endorphin (audio)
: any of a group of endogenous peptides (as enkephalin and dynorphin) found especially in the brain that bind chiefly to opiate receptors and produce some of the same pharmacological effects (as pain relief) as those of opiates
specifically : beta-endorphin

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