Medical Definition of cross–resistance
: tolerance (as of a bacteria, malignant cell, or insect) to a usually toxic substance (as an antibiotic, chemotherapy drug, or pesticide) that is acquired not as a result of direct exposure but by exposure to a related substance The history of drug resistance in falciparum malaria suggests that these compounds may also enjoy only a short-lived glory and that cross-resistance with related compounds can be expected.—David J. Wyler, The Journal of the American Medical Association, 11 May 1984 … paclitaxel and docetaxel are being incorporated into adjuvant regimens on the basis of their antitumor activity in advanced breast cancer and the absence of cross-resistance with doxorubicin.—Charles L. Shapiro, et al., The New England Journal of Medicine, 28 June 2001
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