Medical Dictionary

cleidocranial dysplasia

noun clei·do·cra·ni·al dysplasia \ ˌklī-dō-ˈkrā-nē-əl- \
variants: or cleidocranial dysostosis

medical Definition of cleidocranial dysplasia

:a rare congenital condition characterized especially by partial or complete absence of the clavicles, defective ossification of the skull, and faulty occlusion due to missing, misplaced, or extra teeth
  • Characteristics of cleidocranial dysplasia are alveolar bone abnormalities, impaired dental exfoliation, supernumerary teeth, and lack of cementum in roots.
  • —Bodo Grimbacher et al.The New England Journal of Medicine4 Mar. 1999
Note: Cleidocranial dysplasia is typically inherited as an autosomal dominant trait requiring that one parent pass on a copy of the defective gene on a chromosome other than a sex chromosome.

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