medical Definition of caspase
- … the mitochondria either rupture or leak, ensuring their own demise and releasing a cocktail of factors that trigger protein-splitting enzymes called caspases. The activated caspases then rapidly cleave proteins in the cell's internal skeleton, membranes, and nucleus to bring about the characteristic hallmarks of apoptosis.
- —Elizabeth Finkel, Science, 27 Apr. 2001
- These genes activate the same pathways involved in cellular suicide, or apoptosis. The cells from the Alzheimer's patients had twice as much of a substance, caspase-3, involved in cellular suicide.
- —Jamie Talan, The Dallas Morning News, 10 June 2000