Medical Dictionary calcification noun cal·ci·fi·ca·tion \ ˌkal-sə-fə-ˈkā-shən \ Trending Now: More Trending: lowlife kakistocracy slimeball salacious oligarch SEE ALL See What's Trending Now See More Trending Words What's Trending Now More Trending Words lowlife 'a person of low moral character' kakistocracy 'government by the worst people' slimeball 'a morally repulsive or odious person' salacious 'arousing or appealing to sexual desire' oligarch 'government in which a small group exercises control' SEE ALL medical Definition of calcification 1 : impregnation with calcareous matter: as a : deposition of calcium salts within the matrix of cartilage often as the preliminary step in the formation of bone — compare ossification 1a b : abnormal deposition of calcium salts within soft tissue often causing thickening or hardening 2 : a calcified structure or part; also : an abnormal deposit of calcium salts arterial calcifications Seen and Heard What made you want to look up calcification? Please tell us where you read or heard it (including the quote, if possible). show hide