Medical Dictionary

cadherin

noun cad·her·in \ kad-ˈhir-ən \

medical Definition of cadherin

:any of various glycoproteins that mediate the calcium-dependent adhesion of cells to other cells
Note: Cadherins are composed of polypeptide chains that typically extend through the cell membrane and have a large extracellular part which forms a binding domain. They are usually bound by cadherins present on adjacent cells.
  • The X-ray crystallography showed that adjacent cadherins on the same cell would tend to form pairs. Furthermore, the tip of a cadherin from a neighboring cell would fit neatly between the two members of a pair, forming chemical bonds with both.
  • —Josie GlausiuszDiscoverSeptember 1995
  • Cadherins are critical mediators of metazoan cell adhesion and signaling and provide the structural basis for vital developmental processes, including tissue morphogenesis and maintenance, cell sorting, and cell polarization …
  • —Monika Abedin et al.Science15 Feb. 2008

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