Medical Dictionary

autophosphorylation

play
noun au·to·phos·phor·y·la·tion \ˌȯ-tō-ˌfäs-ˌfȯr-ə-ˈlā-shən\

Medical Definition of autophosphorylation

  1. :  phosphorylation of an organic compound (such as an enzyme) by its own residues Accordingly, if the autophosphorylation of receptor tyrosine kinases is suppressed pharmacologically, the assembly of the downstream signaling complexes may be halted, providing a chance to slow the progression of certain cancers.—John D. Scott and Tony Pawson, Science, 27 Nov. 2009

autophosphorylate

\ˌȯ-tō-ˌfäs-ˈfȯr-ə-ˌlāt\ play transitive verb

autophosphorylated

;

autophosphorylating

The intracellular β-subunit regions, like that of the EGF [epidermal growth factor] receptor, possess tyrosine kinase activity and a tyrosine residue that is autophosphorylated in response to insulin binding.—Keith Wilson, in Principles and Techniques of Practical Biochemistry, 5th edition, 2000

Seen and Heard

What made you want to look up autophosphorylation? Please tell us where you read or heard it (including the quote, if possible).