autophosphorylation

noun
au·​to·​phos·​phor·​y·​la·​tion | \ ˌȯ-tō-ˌfäs-ˌfȯr-ə-ˈlā-shən How to pronounce autophosphorylation (audio) \

Medical Definition of autophosphorylation

: phosphorylation of an organic compound (such as an enzyme) by its own residues Accordingly, if the autophosphorylation of receptor tyrosine kinases is suppressed pharmacologically, the assembly of the downstream signaling complexes may be halted, providing a chance to slow the progression of certain cancers.— John D. Scott and Tony Pawson, Science, 27 Nov. 2009

Other Words from autophosphorylation

autophosphorylate \ ˌȯ-​tō-​ˌfäs-​ˈfȯr-​ə-​ˌlāt How to pronounce autophosphorylate (audio) \ transitive verb autophosphorylated; autophosphorylating
The intracellular β-subunit regions, like that of the EGF [epidermal growth factor] receptor, possess tyrosine kinase activity and a tyrosine residue that is autophosphorylated in response to insulin binding. — Keith Wilson, in Principles and Techniques of Practical Biochemistry, 5th edition, 2000

Learn More about autophosphorylation

Cite this Entry

“Autophosphorylation.” The Merriam-Webster.com Medical Dictionary, Merriam-Webster Inc., https://www.merriam-webster.com/medical/autophosphorylation. Accessed 25 January 2020.

Comments on autophosphorylation

What made you want to look up autophosphorylation? Please tell us where you read or heard it (including the quote, if possible).

WORD OF THE DAY

dull or mediocre

Get Word of the Day daily email!

Test Your Vocabulary

Intact Latin Quiz

  • roman tablet
  • What did focus mean in Latin?
Spell It

Can you spell these 10 commonly misspelled words?

TAKE THE QUIZ
Citation

Test Your Knowledge - and learn some interesting things along the way.

TAKE THE QUIZ
Love words? Need even more definitions?

Subscribe to America's largest dictionary and get thousands more definitions and advanced search—ad free!