Medical Dictionary

autophosphorylation

noun au·to·phos·phor·y·la·tion \ ˌȯ-tō-ˌfäs-ˌfȯr-ə-ˈlā-shən \

medical Definition of autophosphorylation

:phosphorylation of an organic compound (such as an enzyme) by its own residues
  • Accordingly, if the autophosphorylation of receptor tyrosine kinases is suppressed pharmacologically, the assembly of the downstream signaling complexes may be halted, providing a chance to slow the progression of certain cancers.
  • —John D. Scott and Tony PawsonScience27 Nov. 2009

autophosphorylate

play \ˌȯ-tō-ˌfäs-ˈfȯr-ə-ˌlāt\ transitive verb autophosphorylated; autophosphorylating
    • The intracellular β-subunit regions, like that of the EGF [epidermal growth factor] receptor, possess tyrosine kinase activity and a tyrosine residue that is autophosphorylated in response to insulin binding.
    • —Keith Wilson, in Principles and Techniques of Practical Biochemistry, 5th edition2000

Seen and Heard

What made you want to look up autophosphorylation? Please tell us where you read or heard it (including the quote, if possible).

Love words? Need even more definitions?

Subscribe to America's largest dictionary and get thousands more definitions and advanced search—ad free!

WORD OF THE DAY

to speak evil of

Get Word of the Day daily email!

Love words? Need even more definitions?

Subscribe to America's largest dictionary and get thousands more definitions and advanced search—ad free!