au·​to·​phos·​phor·​y·​la·​tion | \ ˌȯ-tō-ˌfäs-ˌfȯr-ə-ˈlā-shən How to pronounce autophosphorylation (audio) \

Medical Definition of autophosphorylation

: phosphorylation of an organic compound (such as an enzyme) by its own residues Accordingly, if the autophosphorylation of receptor tyrosine kinases is suppressed pharmacologically, the assembly of the downstream signaling complexes may be halted, providing a chance to slow the progression of certain cancers.— John D. Scott and Tony Pawson, Science, 27 Nov. 2009

Other Words from autophosphorylation

autophosphorylate \ ˌȯ-​tō-​ˌfäs-​ˈfȯr-​ə-​ˌlāt How to pronounce autophosphorylation (audio) \ transitive verb autophosphorylated; autophosphorylating
The intracellular β-subunit regions, like that of the EGF [epidermal growth factor] receptor, possess tyrosine kinase activity and a tyrosine residue that is autophosphorylated in response to insulin binding. — Keith Wilson, in Principles and Techniques of Practical Biochemistry, 5th edition, 2000

Learn More about autophosphorylation

Cite this Entry

“Autophosphorylation.” Medical Dictionary, Merriam-Webster, Accessed 11 Apr. 2021.

Style: MLA
MLACheck Mark Icon ChicagoCheck Mark Icon APACheck Mark Icon Merriam-WebsterCheck Mark Icon

Comments on autophosphorylation

What made you want to look up autophosphorylation? Please tell us where you read or heard it (including the quote, if possible).


Test Your Vocabulary

The Exceptions Quiz III

  • one green toy robot amidst many red toy robots
  • Which of these words does not mean "nonsense"?
True or False

Test your knowledge - and maybe learn something along the way.

 AlphaBear 2

Spell words. Make bears.

Love words? Need even more definitions?

Subscribe to America's largest dictionary and get thousands more definitions and advanced search—ad free!