Medical Dictionary


noun au·to·phos·phor·y·la·tion \ˌȯ-tō-ˌfäs-ˌfȯr-ə-ˈlā-shən\

Medical Definition of autophosphorylation

  1. :  phosphorylation of an organic compound (such as an enzyme) by its own residues Accordingly, if the autophosphorylation of receptor tyrosine kinases is suppressed pharmacologically, the assembly of the downstream signaling complexes may be halted, providing a chance to slow the progression of certain cancers.—John D. Scott and Tony Pawson, Science, 27 Nov. 2009


\ˌȯ-tō-ˌfäs-ˈfȯr-ə-ˌlāt\ play transitive verb




The intracellular β-subunit regions, like that of the EGF [epidermal growth factor] receptor, possess tyrosine kinase activity and a tyrosine residue that is autophosphorylated in response to insulin binding.—Keith Wilson, in Principles and Techniques of Practical Biochemistry, 5th edition, 2000

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