Medical Dictionary

Arthus reaction

noun Ar·thus reaction \ ˈär-thəs- , ȧr-ˈtᵫ̅s- \
variants: also Arthus phenomenon

medical Definition of Arthus reaction

:a hypersensitivity reaction that occurs several hours to days following the intradermal injection of a vaccine into an animal and is marked by the formation of antigen-antibody complexes accompanied by localized inflammation, pain, redness, and sometimes tissue destruction

Biographical Note for arthus reaction

  • Arthus \ȧr-tᵫ̅s\, Nicolas Maurice (1862–1945), French bacteriologist and physiologist. Arthus was primarily concerned with venoms and antivenins and with coagulability and anticoagulants. In 1890 he published an article on coagulation that demonstrated for the first time the essential role of calcium in blood coagulation. In 1903, in an article reporting a study involving repeated injections of horse serum into rabbits, he reported discovery of the phenomenon of local anaphylaxis, a phenomenon that has since become identified with his name.

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